Studies indicate that amyloid-A-induced upregulation of RAGE leads to a cell stress response in some cases of amyloidosis. Will RAGE blockade be the answer to the toxic effects of amyloid deposits ( pages 643–651)?
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Kisilevsky, R. Amyloids: Tombstones or triggers?. Nat Med 6, 633–634 (2000). https://doi.org/10.1038/76203
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DOI: https://doi.org/10.1038/76203