Abstract
BECAUSE platelet aggregation is probably important in the pathogenesis of thrombosis, interest in this phenomenon is increasing. Hellem1 noted that an acidic, dialysable and heat-stable extract of red cells was able to produce marked platelet aggregation in citrated or oxalated plasma. This red-cell factor was afterwards identified as adenosine diphosphate (ADP) by Gaarder et al.2, who found it to be the most potent of twenty-two nucleotides tested. Other compounds have since been shown to induce platelet aggregation, and these include adenosine triphosphate (ATP)3,4, and certain catecholamines, namely adrenaline5,6 and noradrenaline4,7. In this communication the effects of the three catecholamines, adrenaline, noradrenaline and dopamine, on platelet aggregation induced in vitro by nucleotides are described and discussed.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hellem, A. J., Scand. J. Clin. Lab. Invest., 12, suppl. 51 (1960).
Gaarder, A., Jonsen, J., Laland, S., Hellem, A. J., and Owren, P. A., Nature, 192, 531 (1961).
O'Brien, J. R., J. Clin. Path., 16, 223 (1963).
Mitchell, J. R. A., and Sharp, A. A., Brit. J. Haematol., 10, 78 (1964).
Clayton, S., and Cross, M. J., J. Physiol., 169, 82 (1963).
O'Brien, J. R., Nature, 200, 763 (1963).
O'Brien, J. R., J. Clin. Path., 17, 275 (1964).
Born, G. V. R., Nature, 194, 927 (1962).
Born, G. V. R., and Cross, M. J., J. Physiol., 168, 178 (1963).
Murad, F., Chi, Y. M., Rall, T. W., and Sutherland, E. W., J. Biol. Chem., 237, 1233 (1962).
West, E. S., and Todd, W. R., in Textbook of Biochemistry, third ed., 968 (The Macmillan Company, New York, 1961).
Born, G. V. R., Biochem. J., 62, 33P (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ARDLIE, N., GLEW, G. & SCHWARTZ, C. Influence of Catecholamines on Nucleotide-induced Platelet Aggregation. Nature 212, 415–417 (1966). https://doi.org/10.1038/212415a0
Issue Date:
DOI: https://doi.org/10.1038/212415a0
This article is cited by
-
Anticoagulation and stress-induced cardiomyopathy
Journal of Thrombosis and Thrombolysis (2019)
-
Takotsubo cardiomyopathy complicated with apical thrombus formation on first day of the illness: a case report and literature review
BMC Cardiovascular Disorders (2017)
-
Historical perspective on ADP-induced platelet activation
Purinergic Signalling (2011)
-
Potentiation by adrenaline of human platelet activation and the inhibition by the alpha-adrenergic antagonist nicergoline of platelet adhesion, secretion and aggregation
Agents and Actions (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.