Abstract
THE work of Beutler1 on erythrocyte glutathione ‘instability’ has demonstrated the significance of the glutathione content of red cells for the maintenance of overall erythrocyte structure (and presumably function). In addition, Rigas et al.2 have shown how the interaction of hæmoglobin and oxidized glutathione can lead to increased rates of splenic erythrocyte destruction. A number of disease states have been related to increased instability of erythrocyte glutathione; for example, Theil et al.3 have shown a significant decrease of blood glutathione-levels in patients with acute renal insufficiency.
Similar content being viewed by others
Article PDF
References
Beutler, E., J. Lab. Clin. Med., 49, 84 (1957).
Rigas, D. H., and Kolek, R. D., J. Lab. Clin. Med., 58, 417 (1961).
Theil, G. B., Brodine, C. E., and Doolan, P. D., J. Lab. Clin. Med., 58, 736 (1961).
Altschule, M. D., Siegal, E. P., and Hennaman, D. H., Arch. Neurol. Psychiat., 67, 64 (1952).
Martens, S., Leach, B. E., Heath, R. G., and Cohen, M., Arch. Neurol. Psychiat., 76, 63 (1956).
Easterday, O. D., Featherstone, R. M., Gottlieb, J. S., Nusser, M. L., and Hogg, R. V., Arch. Neurol. Psychiat., 68, 48 (1953).
Barak, A. J., Humoller, F. L., and Stevens, J. D., Arch. Neurol. Psychiat., 80, 237 (1958).
Beutler, E., Duron, D., and Kelly, B. M., J. Lab. Clin. Med., 61, 882 (1963).
Altschule, M. D., Arch. Gen. Psych., 1, 358 (1959).
Biochemists' Handbook, edit. by Long, C., 841 (D. van Nostrand Co., Inc., 1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ELLMAN, G., GAN, G. Erythrocyte Glutathione-levels in Patients of a Mental Hospital. Nature 202, 904 (1964). https://doi.org/10.1038/202904a0
Issue Date:
DOI: https://doi.org/10.1038/202904a0
This article is cited by
-
Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection
Cardiovascular Toxicology (2022)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.