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Fate of Injected Deoxyribonucleic Acid in Mice

Nature volume 198, pages 1088–1089 (1963)Cite this article

Abstract

IN recent years, immunochemical investigations on deoxyribonucleic acid (DNA) have suggested the presence of a specific anti-DNA antibody in sensitized animals and also in patient sera of systemic lupus erythematosus. However, the sensitization of an animal has not always met success, and most of the published results about experimental animals are still open to discussion1. It is needed at present to elucidate the fate of the externally introduced DNA. In this communication, tritiated DNA was used as a tracer.

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References

  1. Kunkel, H. G., Holman, H. R., and Deicher, H. R. G., in Ciba Foundation Symposium on Cellular Aspects of Immunity, edit. by Wolstenholme, G. E. W., and O'Conner. M., 429 (J. and A. Churchill, Ltd., 1960).

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  2. Tsumita, T., Iwanaga, M., and Komai, T., J. Biochem. (in the press).

  3. Schneider, W. C., J. Biol. Chem., 161, 293 (1945).

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Authors and Affiliations

  1. Department of Chemistry, Institute for Infectious Diseases, University of Tokyo,

    TORU TSUMITA & MICHIKO IWANAGA

Authors
  1. TORU TSUMITA
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  2. MICHIKO IWANAGA
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TSUMITA, T., IWANAGA, M. Fate of Injected Deoxyribonucleic Acid in Mice. Nature 198, 1088–1089 (1963). https://doi.org/10.1038/1981088a0

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