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Homologs of RUNX and CBFβ/PEBP2β in C. elegans

Oncogene volume 23, pages 4346–4352 (2004)Cite this article

Abstract

RUNX proteins are evolutionarily well-conserved transcription factors that are involved in essential aspects of the development of metazoan animals ranging from nematodes to humans. Genetic or epigenetic defects in any one of the three RUNX proteins in humans cause severe diseases. Although much is known about the functions and signaling pathways of the RUNX proteins through the use of mammalian systems, there are still gaps in our knowledge with regard to the functions of the RUNX proteins in normal development and disease states. Recently, the nematode Caenorhabditis elegans was revealed to bear one RUNX homolog (RNT-1) and one homolog of the RUNX protein partner CBFβ/PEBP2β (BRO-1). The expression patterns and biological functions of RNT-1 and the manner in which it is regulated are all comparable to what has been observed for the mammalian RUNX proteins. Thus, the nematode system is a promising model system for elucidating the functions and regulation of Runt proteins. In addition, it has recently emerged that the RNT-1 protein is involved in a transforming growth factor beta signaling pathway. The bro-1 gene encoding the CBFβ homolog is exclusively expressed in the hypodermis, not in the intestine, which indicates that additional tissue-specific cofactors in the intestine might exist. The possible autoregulation of RNT-1 expression by RNT-1/BRO-1 in the hypodermal cells is also discussed.

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Acknowledgements

Our studies described in this review were supported by a Biodiscovery Grant (M1-0311-00-0034) to J Lee and by the Creative Research Program (M10301000012) funded by the Ministry of Science and Technology of Korea to S-C Bae. We are also grateful to all the members of their labs for support and critical evaluation of this paper, especially S Nam, J Shim, and Y Ji.

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Authors and Affiliations

  1. Department of Biology, National Research Laboratory, Yonsei University, 134 Shinchon, Seoul, 120-749, Korea

    Junho Lee

  2. Department of Life Science, Kwangju Institute of Science and Technology (K-JIST), 500-712, Gwangju, Korea

    Joohong Ahnn

  3. Department of Biochemistry, Tumor Research Center, College of Medicine, Chungbuk National University, 361-763, Cheongju, Korea

    Suk-Chul Bae

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  1. Junho Lee
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Correspondence to Junho Lee.

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Lee, J., Ahnn, J. & Bae, SC. Homologs of RUNX and CBFβ/PEBP2β in C. elegans. Oncogene 23, 4346–4352 (2004). https://doi.org/10.1038/sj.onc.1207669

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