Abstract
The AP-1 transcription factor is composed of a mixture of homo- and hetero-dimers formed between Jun and Fos proteins. The different Jun and Fos family members vary significantly in their relative abundance and their interactions with additional proteins generating a complex network of transcriptional regulators. Thus, the functional activity of AP-1 in any given cell depends on the relative amount of specific Jun/Fos proteins which are expressed, as well as other potential interacting proteins. This diversity of AP-1 components has complicated our understanding of AP-1 function and resulted in a paucity of information about the precise role of individual AP-1 members in distinct cellular processes. We shall discuss recent studies which suggest that different Jun and Fos family members may have both opposite and overlapping functions in cellular proliferation and cell fate.
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References
Agarwal SK, Guru SC, Heppner C, Erdos MR, Collins RM, Park SY, Saggar S, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ, Burns AL . 1999 Cell 96: 143–152
Alani R, Brown P, Binetruy B, Dosaka H, Rosenberg RK, Angel P, Karin M, Birrer MJ . 1991 Mol. Cell. Biol. 11: 6286–6295
Almendral JM, Sommer D, Bravo MC, Burckhardt H, Perera J, Bravo R . 1988 Mol. Cell. Biol. 8: 2140–2152
Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M . 1988a Nature 332: 166–171
Angel P, Hattori K, Smeal T, Karin . 1988b Cell 55: 875–885
Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M . 1987 Cell 49: 729–739
Angel P, Karin M . 1991 Biochimica et Biophysica Acta 1072: 129–157
Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M . 1994 Nature 370: 226–229
Bakiri L, Lallemand D, Bossy-Wetzel E, Yaniv M . 2000 EMBO J. 19: 2056–2068
Behrens A, Sibilia M, Wagner EF . 1999 Nat. Genet. 21: 326–329
Bos TJ, Monteclaro FS, Mitsunobu F, Ball AJ, Chang CH, Nishimura T, Vogt PK . 1990 Genes Dev. 4: 1677–1687
Bossy-Wetzel E, Bakiri L, Yaniv M . 1997 EMBO J. 16: 1695–1709
Bossy-Wetzel E, Bravo R, Hanahan D . 1992 Genes Dev. 6: 2340–2351
Bouallaga I, Massicard S, Yaniv M, Thierry F . 2000 EMBO Rep. 11: 422–427
Brach MA, Herrmann F, Yamada H, Bauerle PA, Kufe DW . 1992 EMBO J. 11: 1479–1486
Brenner DA, Koch KS, Leffert HL . 1989 DNA 8: 279–285
Castellazzi M, Dangy JP, Mechta F, Hirai S, Yaniv M, Samarut J, Lassailly A, Brun G . 1990 Oncogene 5: 1541–1547
Chalaux E, Lopez-Rovira T, Rosa JL, Bartrons R, Ventura F . 1998 J. Biol. Chem. 273: 537–543
Chiu R, Angel P, Karin M . 1989 Cell 59: 979–986
Coffer P, Lutticken C, van Puijenbroek A, Klop-de Jonge M, Horn F, Kruijer W . 1995 Oncogene 10: 985–994
Colotta F, Polentarutti N, Sironi M, Mantovani A . 1992 J. Biol. Chem. 267: 18278–18283
Cook SJ, Aziz N, McMahon M . 1999 Mol. Cell Biol. 19: 330–341
Curran T, Franza BJ . 1988 Cell 55: 395–397
de Groot R, Auwerx J, Karperien M, Staels B, Kruijer W . 1991a Nucl. Acids Res. 19: 775–781
de Groot R, Karperien M, Pals C, Kruijer W . 1991b EMBO J. 10: 2523–2532
Deng T, Karin M . 1993 Genes Dev. 7: 479–490
Devary Y, Gottlieb RA, Lau LF, Karin M . 1991 Mol. Cell. Biol. 11: 2804–2811
Devary Y, Gottlieb RA, Smeal T, Karin M . 1992 Cell 71: 1081–1091
Dragunow M, Young D, Hughes P, MacGibbon G, Lawlor P, Singleton K, Sirimanne E, Beilharz E, Gluckman P . 1993 Brain Res. Mol. Brain Res. 18: 347–352
Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K . 1999 J. Cell Biol. 145: 1049–1061
Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EJ . 1994 J. Cell Biol. 127: 1717–1727
Feig LA, Cooper GM . 1988 Mol. Cell. Biol. 8: 3235–3243
Gajate C, Alonso MT, Schimmang T, Mollinedo F . 1996 Biochem. Biophys. Res. Commun. 218: 267–272
Gentz R, Rauscher FJD, Abate C, Curran T . 1989 Science 243: 1695–1699
Gupta S, Campbell D, Derijard B, Davis RJ . 1995 Science 267: 389–393
Hagmeyer BM, Konig H, Herr I, Offringa R, Zantema A, van der Eb A, Herrlich P, Angel P . 1993 EMBO J. 12: 3559–3572
Hai T, Curran T . 1991 Proc. Natl. Acad. Sci. USA 88: 3720–3724
Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P . 1988 Cell 55: 917–924
Ham J, Babij C, Whitfield J, Pfarr CM, Lallemand D, Yaniv M, Rubin LL . 1995 Neuron 14: 927–939
Herschman HR . 1991 Annu. Rev. Bioch. 60: 281–319
Herzog KH, Chen SC, Morgan JI . 1999 J. Neurosci. 19: 4349–4359
Hilberg F, Aguzzi A, Howells N, Wagner EF . 1993 Nature 365: 179–181
Hill CS, Treisman R . 1995 Cell 80: 199–211
Hirai SI, Bourachot B, Yaniv M . 1990 Oncogene 5: 39–46
Hirai SI, Ryseck RP, Mechta F, Bravo R, Yaniv M . 1989 EMBO J. 8: 1433–1439
Hirai SI, Yaniv M . 1989 New Biologist 1: 181–191
Johnson R, Spiegelman B, Hanahan D, Wisdom R . 1996 Mol. Cell. Biol. 16: 4504–4511
Johnson RS, van LB, Papaioannou VE, Spiegelman BM . 1993 Genes Dev. 7: 1309–1317
Jonk LJ, Itoh S, Heldin CH, ten Dijke P, Kruijer W . 1998 J. Biol. Chem. 273: 21145–21152
Kallunki T, Deng T, Hibi M, Karin M . 1996 Cell 87: 929–939
Karin M, Hunter T . 1995 Curr Biol 5: 747–757
Karin M, Liu Z, Zandi E . 1997 Curr. Opin. Cell Biol. 9: 240–246
Kataoka K, Fujiwara KT, Noda M, Nishizawa M . 1994 Mol. Cell. Biol. 14: 7581–7591
Kawakami Z, Kitabayashi I, Matsuoka T, Gachelin G, Yokoyama K . 1992 Nucleic Acids Res. 20: 914
Kawasaki M, Hisamoto N, Iino Y, Yamamoto M, Ninomiya-Tsuji J, Matsumoto K . 1999 EMBO J. 18: 3604–3615
Kerppola TK, Curran T . 1991a Science 254: 1210–1214
Kerppola TK, Curran T . 1991b Cell 66: 317–326
Kerppola TK, Curran T . 1994 Oncogene 9: 675–684
Kitabayashi I, Kawakami Z, Matsuoka T, Chiu R, Gachelin G, Yokoyama K . 1993 J. Biol. Chem. 268: 14482–14489
Knochel S, Schuler-Metz A, Knochel W . 2000 Mech. Dev. 98: 29–36
Kouzarides T, Ziff E . 1988 Nature 336: 646–651
Kovary K, Bravo R . 1991a Mol. Cell. Biol. 11: 2451–2459
Kovary K, Bravo R . 1991b Mol. Cell. Biol. 11: 4466–4472
Kovary K, Bravo R . 1992 Mol. Cell. Biol. 12: 5015–5023
Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA . 1999 Neuron 22: 667–676
Lallemand D, Spyrou G, Yaniv M, Pfarr CM . 1997 Oncogene 14: 819–830
Landschulz WH, Johnson PF, McKnight SL . 1988 Science 240: 1759–1764
Lau LF, Nathans D . 1987 Proc. Natl. Acad. Sci. 84: 1182–1186
Lenczowski JM, Dominguez L, Eder AM, King LB, Zacharchuk CM, Ashwell JD . 1997 Mol. Cell. Biol. 17: 170–181
Leppa S, Saffrich R, Ansorge W, Bohmann D . 1998 EMBO J. 17: 4404–4413
Li B, Tournier C, Davis RJ, Flavell RA . 1999 EMBO J. 18: 420–432
Liu JJ, Chao JR, Jiang MC, Ng SY, Yen JJ, Yang-Yen HF . 1995 Mol. Cell. Biol. 15: 3654–3663
Liu ZG, Baskaran R, Lea CE, Wood LD, Chen Y, Karin M, Wang JY . 1996 Nature 384: 273–276
Lloyd A, Yancheva N, Wasylyk B . 1991 Nature 352: 635–638
Lopez-Rovira T, Chalaux E, Rosa JL, Bartrons R, Ventura F . 2000 J. Biol. Chem. 275: 28937–28946
Manome Y, Datta R, Taneja N, Shafman T, Bump E, Hass R, Weichselbaum R, Kufe D . 1993 Biochemistry 32: 10607–10613
Mechta F, Lallemand D, Pfarr CM, Yaniv M . 1997 Oncogene 14: 837–847
Mechta F, Piette J, Hirai SI, Yaniv M . 1989 New Biologist 1: 297–304
Mechta F, Yaniv M . (1994). In The Fos and Jun families of transcription factors CRC Press 115–129
Mulcahy LS, Smith MR, Stacey DW . 1985 Nature 241: 241–243
Nakajima K, Kusafuka T, Takeda T, Fujitani Y, Nakae K, Hirano T . 1993 Mol. Cell Biol. 13: 3027–3041
Neyns B, Katesuwanasing Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGreve J . 1996 Oncogene 12: 1247–1257
Noselli S . 1998 Trends in Genetics 14: 33–38
Passégue E, Jochum W, Schorpp-Kistner M, Möhle-Steinlein U, Wagner EF . 2001 Cell 104: 21–32
Passégue E, Wagner EF . 2000 EMBO J. 19: 2969–2979
Pfarr CM, Mechta F, Spyrou G, Lallemand D, Carillo S, Yaniv M . 1994 Cell 76: 747–760
Phinney DG, Keiper CL, Francis MK, Ryder K . 1994 Oncogene 9: 2353–2362
Piette J, Hirai S, Yaniv M . 1988 Proc. Natl. Acad. Sci. 85: 3401–3405
Piette J, Kryske MH, Yaniv M . 1987 Mol. Aspects of Papovavirus 87–100
Preston GA, Lyon TT, Yin Y, Lang JE, Solomon G, Annab L, Srinivasan DG, Alcorta DA, Barrett JC . 1996 Mol. Cell. Biol. 16: 211–218
Ransone LJ, Visvader J, Sassone CP, Verma IM . 1989 Genes Dev. 3: 770–781
Rauscher FD, Voulalas PJ, Franza BJ, Curran T . 1988 Genes Dev. 2: 1687–1699
Rebollo A, Dumoutier L, Renauld JC, Zaballos A, Ayllon V, Martinez AC . 2000 Mol. Cell Biol. 20: 3407–3416
Riabowol K, Schiff J, Gilman MZ . 1992 Proc. Natl. Acad. Sci. USA 89: 157–161
Riesgo-Escovar JR, Hafen E . 1997 Science 278: 669–672
Robles AI, Rodriguez-Puebla ML, Glick AB, Trempus C, Hansen L, Sicinski P, Tennant RW, Weinberg RA, Yuspa SH, Conti CJ . 1998 Genes Dev. 12: 2469–2474
Rozek D, Pfeifer GP . 1993 Mol. Cell Biol. 13: 5490–5499
Ryseck RP, Bravo R . 1991 Oncogene 6: 533–542
Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF . 1999 Mech. Dev. 89: 115–124
Sassone-Corsi P, Lamph WW, Kamps M, Verma IM . 1988 Cell 54: 553–560
Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF . 1999 EMBO J. 18: 934–948
Schreiber M, Kolbus A, Piu F, Szabowski A, Mohle-Steinlein U, Tian J, Karin M, Angel P, Wagner E . 1999 Genes Dev. 13: 607–619
Schreiber M, Wang Z, Jochum W, Fetka I, Elliott C, Wagner EF . 2000 Development 127: 4937–4948
Schuermann M, Neuberg M, Hunter JB, Jenuwein T, Ryseck RP, Bravo R, Muller R . 1989 Cell 56: 507–516
Schütte J, Minna JD, Birrer MJ . 1989 Proc. Natl. Acad. Sci. 86: 2257–2261
Schutte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J . 1989 Cell 59: 987–997
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW . 1997 Cell 88: 593–602
Sharma SC, Richards JS . 2000 J. Biol. Chem. 275: 33718–33728
Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M . 2000 Cell 103: 897–907
Sjin RM, Lord KA, Abdollahi A, Hoffman B, Lebermann DA . 1999 J. Biol. Chem. 274: 28697–28707
Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M . 1991 Nature 354: 494–496
Smith MJ, Prochownik EV . 1992 Blood 79: 2107–2115
Smith MR, De Gudicibus SJ, Stacey DW . 1989 Nature 320: 540–543
Stein B, Angel P, van DH, Ponta H, Herrlich P, van der Eb A, Rahmsdorf HJ . 1992 Photochem. Photobiol. 55: 409–415
Suzuki T, Murakami M, Onai N, Fukuda E, Hashimoto Y, Sonobe MH, Kameda T, Ichinose M, Miki K, Iba H . 1994 J. Virol. 68: 3527–3535
Suzuki T, Okuno H, Yoshida T, Endo T, Nishina H, Iba H . 1991 Nucl. Acid. Res. 19: 5537–5542
Szabowski A, Maas-Szabowski N, Andrecht S, Kolbus A, Schropp-Kistner M, Fusenig NE, Angel P . 2000 Cell 103: 745–755
Thepot D, Weitzman JB, Barra J, Segretain D, Stinnakre MG, Babinet C, Yaniv M . 2000 Development 127: 143–153
Thierry F, Spyrou G, Yaniv M, Howley P . 1992 J. Virol. 66: 3740–3748
Turner R, Tjian R . 1989 Science 243: 1689–1694
van Dam H, Duyndam M, Rottier R, Bosch A, de Vries-Smits L, Herrlich P, Zantema A, Angel P, van der Eb AJ . 1993 EMBO J. 12: 479–487
van Dam H, Huguier S, Kooistra K, Baguet J, Vial E, van der Eb AJ, Herrlich P, Angel P, Castellazzi M . 1998 Genes Dev. 12: 1227–1239
Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN . 1996 Nature 380: 75–79
Vogt PK, Bos TJ . 1990 Adv. Cancer Res. 55: 1–35
Vogt PK, Bos TJ, Mitsunobu F, Nishimura T, Monteclaro FS, Su HY . 1989 Int. Symp. Princess Takamatsu Cancer Res. Fund 20: 127–134
Wang H, Birkenbach M, Hart J . 2000 Carcinogenesis 21: 1313–1317
Wang ZQ, Liang J, Schellander K, Wagner EF, Grigoriadis AE . 1995 Cancer Res. 55: 6244–6251
Watson A, Eilers A, Lallemand D, Kyriakis J, Rubin LL, Ham J . 1998 J. Neurosci. 18: 751–762
Weitzman JB, Fiette L, Matsuo K, Yaniv M . 2000 Mol. Cell 6: 1109–1119
Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA . 1994 Proc. Natl. Acad. Sci. USA 91: 6030–6034
Wilkinson DG, Bhatt S, Ryseck RP, Bravo R . 1989 Development 106: 465–471
Wisdom R, Johnson RS, Moore C . 1999 EMBO J. 18: 188–197
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME . 1995 Science 270: 1326–1331
Zhang K, Chaillet JR, Perkins LA, Halazonetis TD, Perrimon N . 1990 Proc. Natl. Acad. Sci. USA 87: 6281–6285
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Mechta-Grigoriou, F., Gerald, D. & Yaniv, M. The mammalian Jun proteins: redundancy and specificity. Oncogene 20, 2378–2389 (2001). https://doi.org/10.1038/sj.onc.1204381
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