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Arterial hypertension increases left ventricular mass: role of tight blood pressure control

Journal of Human Hypertension volume 18, pages 637–642 (2004)Cite this article

Abstract

In middle-age hypertensives from the Gubbio Population Study, we evaluated the relationship between blood pressure (BP) control over a long time and the prevalence of left ventricular hypertrophy (LVH). A population survey was performed in 1982–1985 and repeated in 1989–1992. During the second survey, subjects in the age range 40–60 years were invited to undergo an M-mode echocardiographic examination. A total of 487 subjects who participated in both surveys are included in the present analysis. Some of them (294) were normotensive (Group 1), 110 were hypertensive but had never taken antihypertensive drugs (Group 2), 47 hypertensives on drugs were in good BP control (Group 3) and 36 hypertensives on drugs had uncontrolled hypertension (Group 4). BP values at the 1989–1992 examination were, respectively, 122/77, 145/86, 124/78 and 153/91 mmHg, while 7 years earlier were 122/77, 133/84, 136/85 and 152/95 mmHg. Despite normal BP levels in Group 3, left ventricular mass index (LVMi, g/m2.7) was greater than in normotensives (42.4±10, 46.6±13, 47.0±10, 51.9±15 g/m2.7). Accordingly, the prevalence of LVH (LVMi >51 g/m2.7) was 18, 26.4, 36.7 and 50% in groups 1–4, respectively. The 193 hypertensives were, thereafter, divided according to BP control (ie <140/90 mmHg) on both surveys (1983–1985 and 1989–1992): 27 hypertensives with optimal BP levels on both visits also had a ventricular mass similar to normotensives and significantly lower than the other hypertensives (LVMi 44.6±11.6 vs 48.5±13.2, P<0.001). In conclusion, these findings indicate that hypertensive patients with BP values at levels similar to those in normotensives for a long period do not increase their left ventricular mass in comparison to subjects with normal BP levels.

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Author notes

  1. O Cardoni: Deceased.

Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Federico 2nd University of Naples, Italy

    L A Ferrara, O Vaccaro & M Mancini

  2. Ospedale di Gubbio,

    O Cardoni

  3. Centro di Fisiologia Clinica ed Ipertensione, Università di Milano, Ospedale Maggiore and Istituto Auxologico Italiano, Milano, Italy

    A Zanchetti

Authors
  1. L A Ferrara
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  2. O Vaccaro
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  3. O Cardoni
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  4. M Mancini
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  5. A Zanchetti
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Corresponding author

Correspondence to L A Ferrara.

Additional information

This study was supported in part by an NIH grant and by Merck Sharp and Dohme.

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Ferrara, L., Vaccaro, O., Cardoni, O. et al. Arterial hypertension increases left ventricular mass: role of tight blood pressure control. J Hum Hypertens 18, 637–642 (2004). https://doi.org/10.1038/sj.jhh.1001698

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  • DOI: https://doi.org/10.1038/sj.jhh.1001698

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