Abstract
Genetic association studies are the most frequent type of study performed in the investigation of the genetic basis of complex cardiovascular conditions. While relatively easy to perform, and having previously correctly identified genetic effects subsequently proven to be due to genetic linkage, interpretation of the results of these studies is not always straightforward. Issues such as population stratification, data-driven subgroup analysis, possible absence of linkage disequilibrium between marker and disease locus, and testing of multiple hypotheses are discussed and the likely place for association studies in a strategy involving studies of a variety of designs geared to finding genetic determinants of disease susceptibility is addressed.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Keavney, B. Genetic association studies in complex diseases. J Hum Hypertens 14, 361–367 (2000). https://doi.org/10.1038/sj.jhh.1001020
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.jhh.1001020
Keywords
This article is cited by
-
The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
BMC Medical Genetics (2009)
-
Association study designs for complex diseases
Nature Reviews Genetics (2001)