Abstract
CTLA-4 is an important negative regulator of the immune system. The regulation of the CTLA-4 gene (Ctla-4) transcription is poorly understood. A single nucleotide polymorphism (SNP) at −318 in the Ctla-4 promoter region is associated with certain autoimmune diseases. Since the −318 SNP occurs in a potential regulatory region, it is conceivable that the C′ T transition may affect the expression of Ctla-4. In the present study, we show that the −318T allele is associated with a higher promoter activity than the −318C allele (8.13 ± 0.46 vs 6.87 ± 0.49). The presence of the −318T allele may thus contribute to up regulation of the expression of CTLA-4, and consequently represent one mechanism to inhibit exaggerated immune activity.
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This study was supported by grants the Swedish Research Council, the Gustaf V: s 80-years Foundation, the Swedish Rheumatism Association and the Börje Dahlin Foundation
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Wang, X., Zhao, X., Giscombe, R. et al. A CTLA-4 gene polymorphism at position −318 in the promoter region affects the expression of protein. Genes Immun 3, 233–234 (2002). https://doi.org/10.1038/sj.gene.6363869
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DOI: https://doi.org/10.1038/sj.gene.6363869
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