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Post-Transplant Events

Effects of various antireabsorptive treatments on bone mineral density in hypogonadal young women after allogeneic stem cell transplantation

Bone Marrow Transplantation volume 37, pages 81–88 (2006)Cite this article

Abstract

Ovarian failure after allogeneic stem cell transplant (allo-SCT) is an important risk factor for development of osteoporosis. We investigated the effects of various antiresorptive treatments in long-term surviving females with ovarian failure after allo-SCT. A total of 60 women with osteoporosis or osteopenia were divided randomly into four groups of 15 women each. Group 1 was treated with calcium and vitamin D alone, group 2 received the same treatment in combination with hormone replacement therapy (HRT), group 3 received risedronate (35 mg weekly, orally for 1 year) and group 4 zoledronic acid (3 monthly doses of 4 mg (intravenous)). All groups were similar for age, body mass index, underlying disease and time elapsed from transplant. Lumbar and femoral bone mineral density (BMD) were measured at baseline and after 12 months, together with serum osteocalcin and urinary hydroxyproline. At 12 months, a significant decrease in lumbar and femoral BMD was observed in group 1 and a milder decrease in group 2. Risedronate treatment increased significantly lumbar BMD and prevented bone loss at the femoral neck. Zoledronic acid increased significantly both lumbar and femoral BMD. In groups 3 and 4 the hydroxyproline excretion was significantly reduced, while osteocalcin mildly increased only in group 4. In conclusion, bisphosphonate administration is useful to prevent and treat bone demineralization in young adult women after allo-SCT.

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Acknowledgements

Supported in part by grants from Ministero dell’Università e della Ricerca Scientifica e Tecnologica (MURST), from Regione Campania and from Associazione Italiana Leucemie Linfomi (AIL) Salerno.

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Authors and Affiliations

  1. Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy

    L Tauchmanovà, T Musella, F Orio, G Lombardi & A Colao

  2. Division of Hematology, Federico II University of Naples, Naples, Italy

    G De Simone, P Ricci, B Rotoli & C Selleri

  3. Department of Gynecology, Obstetrics and Physiopathology of Reproduction, Federico II University of Naples, Naples, Italy

    C Nappi

Authors
  1. L Tauchmanovà
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  2. G De Simone
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  4. F Orio
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  7. G Lombardi
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Correspondence to C Selleri.

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Tauchmanovà, L., De Simone, G., Musella, T. et al. Effects of various antireabsorptive treatments on bone mineral density in hypogonadal young women after allogeneic stem cell transplantation. Bone Marrow Transplant 37, 81–88 (2006). https://doi.org/10.1038/sj.bmt.1705196

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