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Myeloid Reconstitution

Prognostic importance of the platelet count 100 days post allogeneic bone marrow transplant

Bone Marrow Transplantation volume 33, pages 419–423 (2004)Cite this article

Summary:

We assessed the prognostic importance of the platelet count 100 days post transplant of 107 consecutive patients receiving ablative allogeneic bone marrow transplant (BMT) between 7/96 and 12/00 who survived at least 100 days. Diagnoses included AML (n=36), chronic myelogenous leukemia (n=27), NHL (n=14), ALL (n=16), MDS (n=9), aplastic anemia (n=3), and one Hodgkin's disease and myelofibrosis each. In total, 64% were in remission or in chronic phase or had aplastic anemia (good risk), and 36% had active disease at the time of transplant (bad risk). In all, 70% were matched sibling transplants and 30% were matched unrelated donor transplants. The mean follow-up for the patients remaining alive is 48 months. Survival was powerfully influenced by the 100-day platelet count: 4-year survival was 19% for patients with a platelet count <30 × 109/l; 41% for patients with a platelet count of 30–50; and 72% for those with a platelet count >50 (P<0.001; log-rank test). In a multivariable analysis, the most powerful risk factors for mortality after allogeneic BMT were low 100-day platelet count (P<0.001) and bad risk disease (P=0.009). We conclude that the platelet count 100 days post transplant is a powerful predictor of overall survival.

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH, USA

    B Bolwell, B Pohlman, R Sobecks, S Andresen, S Brown, V Wentling & M Kalaycio

  2. Department of Biostatistics and Epidemiology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH, USA

    L Rybicki

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  1. B Bolwell
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  2. B Pohlman
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  3. R Sobecks
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  7. V Wentling
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  8. M Kalaycio
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Correspondence to B Bolwell.

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Bolwell, B., Pohlman, B., Sobecks, R. et al. Prognostic importance of the platelet count 100 days post allogeneic bone marrow transplant. Bone Marrow Transplant 33, 419–423 (2004). https://doi.org/10.1038/sj.bmt.1704330

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  • DOI: https://doi.org/10.1038/sj.bmt.1704330

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