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Topical azathioprine in the combined treatment of chronic oral graft-versus-host disease

Bone Marrow Transplantation volume 25, pages 683–687 (2000)Cite this article

Abstract

This paper presents the first report of the use of topical azathioprine in the management of persistent symptomatic chronic oral graft-versus-host disease (GVHD). Topical azathioprine suspension was used as an oral rinse and was swallowed, maintaining the previously prescribed systemic dose of azathioprine, and resulted in improvement in a case of oral GVHD that was resistant to other approaches to management. Topical azathioprine may provide additional therapy in the management of immune-mediated oral mucosal disease. Clinical trials appear warranted based upon the results of topical azathioprine use as presented in this case report. Bone Marrow Transplantation (2000) 25, 683–687.

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Authors and Affiliations

  1. British Columbia Cancer Agency, Vancouver Hospital and Health Sciences Centre, University of British Columbia, Vancouver, BC, Canada

    JB Epstein & S Nantel

  2. University of Washington, Seattle, WA, USA

    JB Epstein

  3. University of California SF, San Francisco, CA, USA

    SM Sheoltch

  4. Leukemia, Bone Marrow Transplantation Program of BC, Canada

    S Nantel

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  1. JB Epstein
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  2. S Nantel
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  3. SM Sheoltch
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Epstein, J., Nantel, S. & Sheoltch, S. Topical azathioprine in the combined treatment of chronic oral graft-versus-host disease. Bone Marrow Transplant 25, 683–687 (2000). https://doi.org/10.1038/sj.bmt.1702192

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  • DOI: https://doi.org/10.1038/sj.bmt.1702192

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