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Natriuretic peptides in bronchopulmonary dysplasia: a systematic review

Journal of Perinatology volume 40, pages 607–615 (2020)Cite this article

Subjects

Abstract

Objectives

To systematically review the diagnostic accuracy of brain natriuretic peptide (BNP) and amino-terminal pro-B-type natriuretic peptide (NT-proBNP) in bronchopulmonary dysplasia (BPD) and BPD-pulmonary hypertension (PH).

Study design

PubMed, Embase, the Web of Science, and the Cochrane Library were searched in March 2019. We included studies that evaluated BNP or NT-proBNP in preterm neonates as a marker for predicting BPD, BPD or death, and BPD-PH.

Results

Nine studies evaluating NT-proBNP/BNP were included. The quality of evidence was low, using GRADE criteria. The diagnostic accuracy of NT-proBNP and BNP for diagnosing BPD-PH showed high sensitivity and specificity in infants with BPD. Lower sensitivities and specificities of NT-proBNP and BNP were reported for predicting BPD, BPD or death, compared with that for BPD-PH.

Conclusions

Low quality evidence suggests that NT-proBNP and BNP have adequate diagnostic accuracy for diagnosing and monitoring BPD-PH and may be used to triage patients to receive an echocardiogram.

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Fig. 1: PRISMA flow diagram.
Fig. 2: Assessment of methodological quality of studies.
Fig. 3: Forest plot of sensitivity and specificity of included studies.
Fig. 4: Summary receiver operating characteristic plot for NT-proBNP and BNP.

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Authors and Affiliations

  1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan, China

    Tao Xiong

  2. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China

    Tao Xiong

  3. Section of Neonatology, Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, 77030, USA

    Madhulika Kulkarni, Ganga Gokulakrishnan, Binoy Shivanna & Mohan Pammi

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  1. Tao Xiong
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  2. Madhulika Kulkarni
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  3. Ganga Gokulakrishnan
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  4. Binoy Shivanna
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Contributions

Conceived the review: TX, MK, and MP. Designed the review: TX, MK and MP. Coordinated the review: all authors. Designed the search strategies: all authors. Extracted the data: TX, MK, and MP. Wrote the review: all authors. Provided guidance on review methods: MP.

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Correspondence to Mohan Pammi.

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Xiong, T., Kulkarni, M., Gokulakrishnan, G. et al. Natriuretic peptides in bronchopulmonary dysplasia: a systematic review. J Perinatol 40, 607–615 (2020). https://doi.org/10.1038/s41372-019-0588-2

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