The SUPPORT trial evaluated the effect of adding the angiotensin-receptor blocker olmesartan to a combination of angiotensin-converting-enzyme inhibitors and β-blockers in hypertensive patients with chronic stable heart failure. Unfortunately, this triple renin–angiotensin–aldosterone system blockade was associated with worsening of renal function and increases in cardiac events and mortality.
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Danser, A., van den Meiracker, A. New data do not SUPPORT triple RAAS blockade. Nat Rev Nephrol 11, 260–262 (2015). https://doi.org/10.1038/nrneph.2015.30
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DOI: https://doi.org/10.1038/nrneph.2015.30