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Metabolism

Irisin, the metabolic syndrome and follistatin in humans

Many important associations have been found between the newly discovered myokine irisin and measures of metabolic disease. However, not much is known regarding the role of irisin in human disease. Two recent reports now identify novel metabolic associations for this molecule in humans.

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References

  1. Boström, P. et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481, 463–468 (2012).

    Article  Google Scholar 

  2. Park, K. H. et al. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2013-2373.

  3. Vamvini, M. T. et al. Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans. Eur. J. Endocrinol. 169, 829–834 (2013).

    Article  CAS  Google Scholar 

  4. Zhang, H. J. et al. Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J. Hepatol. 59, 557–562 (2013).

    Article  CAS  Google Scholar 

  5. Raschke, S. et al. Evidence against a beneficial effect of irisin in humans. PLoS ONE 8, e73680 (2013).

    Article  CAS  Google Scholar 

  6. Erickson, H. P. Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor? Adipocyte 2, 289–293 (2013).

    Article  CAS  Google Scholar 

  7. Huh, J. Y. et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61, 1725–1738 (2012).

    Article  CAS  Google Scholar 

  8. Ivanov, I. P., Firth, A. E., Michel, A. M., Atkins, J. F. & Baranov, P. V. Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences. Nucleic Acids Res. 39, 4220–4234 (2011).

    Article  CAS  Google Scholar 

  9. Moreno-Navarrete, J. M. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J. Clin. Endocrinol. Metab. 98, E769–E778 (2013).

    Article  CAS  Google Scholar 

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Correspondence to Pontus A. Boström.

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Boström, P., Fernández-Real, J. Irisin, the metabolic syndrome and follistatin in humans. Nat Rev Endocrinol 10, 11–12 (2014). https://doi.org/10.1038/nrendo.2013.230

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