Abstract
Cancer develops from normal tissues through the accumulation of genetic alterations that act in concert to confer malignant phenotypes. Although we have now identified some of the genes that when mutated initiate tumor formation and drive cancer progression, the identity of the cell population(s) susceptible to such transforming events remains undefined for the majority of human cancers. Recent work indicates that a small population of cells endowed with unique self-renewal properties and tumorigenic potential is present in some, and perhaps all, tumors. Although our understanding of the biology of these putative cancer stem cells remains rudimentary, the existence of such cells has implications for current conceptualizations of malignant transformation and therapeutic approaches to cancer.
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Acknowledgements
We apologize to our colleagues whose work could not be cited due to space limitations. We thank R. Weinberg, C. Kim, K. Cichowski, C. Sawyers, M. Brown and B. Vogelstein for comments and discussion. We recognize support from the US National Institutes of Health (R01 CA94074, P50 CA89393, K01 94223 and R01 AG23145), the Tisch Family Fund for Research in Solid Tumors, the US Army Medical Research and Material Command (DAMD17 02 1 0692 and W8IXWH-04-1-0452) and the American Cancer Society (RSG-05-154-01-MGO). The authors are consultants for Novartis Pharmaceuticals, Inc.
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Kornelia Polyak and William C. Hahn are consultants for Novartis Pharmaceuticals, Inc.
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Polyak, K., Hahn, W. Roots and stems: stem cells in cancer. Nat Med 12, 296–300 (2006). https://doi.org/10.1038/nm1379
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DOI: https://doi.org/10.1038/nm1379