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γδ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis

Nature Medicine volume 1, pages 552–557 (1995)Cite this article

Abstract

Despite the prevalence of γδ T cells in mucosae that are typically colonized by Candida albicans, little is known of the possible role of these cells in resistance to candidiasis. A sharp increase in the number of γδ T cells and macrophages following intraperitoneal inoculation of mice with C. albicans led us to examine the role of these cells in the immune response to C. albicans. We show that the γδT cells enhance macrophage nitric oxide (NO) production and anti-candida activity, in vitro. We also propose that the γδ T cells regulate macrophage function during candidiasis in vivo as well, because depletion of these cells abrogated inducible NO synthase expression in mucosae and enhanced murine susceptibility to candidiasis.

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Author information

Authors and Affiliations

  1. Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin, 53706-1532, USA

    Jessica Jones-Carson, Andres Vazquez-Torres, R. Doug Wagner & Edward Balish

  2. Departments of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin, 53706-1532, USA

    Henri C. van der Heyde & Thomas Warner

Authors
  1. Jessica Jones-Carson
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  2. Andres Vazquez-Torres
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  3. Henri C. van der Heyde
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  4. Thomas Warner
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  5. R. Doug Wagner
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  6. Edward Balish
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Department of Surgical Pathology, University of Wisconsin Medical School, Madison, Wisconsin, 53706-1532, USA

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Jones-Carson, J., Vazquez-Torres, A., van der Heyde, H. et al. γδ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis. Nat Med 1, 552–557 (1995). https://doi.org/10.1038/nm0695-552

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