After myocardial infarction (MI), circulating B cells produce the chemokine Ccl7, which mobilizes inflammatory monocytes from the bone marrow into the blood, after which they are then recruited to the injured heart, a new study shows. B cell depletion after MI limits myocardial injury and improves heart function, suggesting a new approach for the management of acute MI (pages 1273–1280).
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Kim, N., Luster, A. To B or not to B—that is the question for myocardial infarction. Nat Med 19, 1208–1210 (2013). https://doi.org/10.1038/nm.3367
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DOI: https://doi.org/10.1038/nm.3367
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