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Environment, lifestyle and infertility — an inter-generational issue

Abstract

The effects of adult lifestyle — primarily smoking and diet in women, and sedentary habits generally — are important factors affecting the fertility of men and women, and can also impact the fertility of their children. This review summarizes the effects of season, modern lifestyles and environmental chemicals on human fertility, and discusses the implications of these effects for future generations.

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Figure 1: Factors affecting sperm counts in adult men and their role in fertility.
Figure 2: Key environmental/lifestyle factors than can affect human fertility.
Figure 3: The hormonal mechanisms that link nutrition/diet and female fertility.

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References

  1. Lincoln, G.A. and Short, R.V. Seasonal breeding: Nature's contraceptive. Rec. Progr. Horm. Res. 36, 1–52 (1980).

    CAS  PubMed  Google Scholar 

  2. Lincoln, G.A., Rhind, S.M., Pompolo, S. & Clarke, I.J. Hypothalamic control of photoepriod-induced cycles in food intake, body weight and metabolic hormones in rams. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R76–R90 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Crisp, T.M., Clegg, E.D., Cooper, R.L., Wood, W.P. & Anderson, D.G. Environmental endocrine disruption: an effects assessment and analysis. Environ. Health Perspect. 106, Suppl. 1, 11–56 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Sharpe, R.M. Environmental oestrogens and male infertility. Pure Appl. Chem. 70, 1685–1701 (1998).

    Article  CAS  Google Scholar 

  5. Sharpe, R.M. Environment, lifestyle and male infertility. Baillieres Clin. Endocr. Metab. 14, 489–503 (2000).

    CAS  Google Scholar 

  6. Hughes, I.A. Minireview: sex differentiation. Endocrinology 142, 3281–3287 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Sharpe, R.M. Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicol. Lett. 120, 221–232 (2001).

    Article  CAS  PubMed  Google Scholar 

  8. Haffner, S.M. Sex hormone-binding protein, hyper-insulinaemia, insulin resistance and noninsulin-dependent diabetes. Horm. Res. 45, 233–237 (1996).

    Article  CAS  PubMed  Google Scholar 

  9. Irvine, D.S. Epidemiology and aetiology of male infertility. Hum. Reprod. Suppl. 1, 33–44 (1998).

    Article  Google Scholar 

  10. Bonde, J.P. et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 352, 1172–1177 (1998).

    Article  CAS  PubMed  Google Scholar 

  11. Guzick, D.S, Overstreet, J.W., Factor-Litvack, P., Brazil, C.K. & Nakajima, S.T. Sperm morphology, motility and concentration in fertile and infertile men N. Engl. J. Med. 345, 1388–1393 (2001).

    Article  CAS  PubMed  Google Scholar 

  12. Slama, R., Eustache, F., Ducot, B., Jensen, T.K. & Jorgensen, N. Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. Hum. Reprod. 17, 503–515 (2002).

    Article  CAS  PubMed  Google Scholar 

  13. Sharpe, R.M. Fetal/neonatal hormones and reproductive function of the male in adulthood in Fetal programming: influences on development and disease in later life. (Eds O'Brien, P.M.S., Wheeler, T. & Barker, D.J.P) 187–194 (Royal College of Obstetricians & Gynaecologists Press, London, 1999).

    Google Scholar 

  14. Johnson, L., Zane, R.S., Petty, C.S. & Neaves, W. Quantification of the human Sertoli cell population: its distribution, relation to germ cell numbers and age-related decline. Biol. Reprod. 31, 785–795 (1984).

    Article  CAS  PubMed  Google Scholar 

  15. Cortes, D., Muller, J. & Skakkebaek, N.E. Proliferation of Sertoli cells during development of the human testis assessed by stereological methods. Int. J. Androl. 10, 589–596 (1987).

    Article  CAS  PubMed  Google Scholar 

  16. Toppari, J. et al. Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 104, Suppl. 4, 741–803 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Boisen, K.A., Main, K.M., Rajpert-de Meyts, E. & Skakkebaek, N.E. Are male reproductive disorders a common entity? The testicular dysgenesis syndrome. Ann. NY Acad. Sci. 948, 90–99 (2001).

    Article  CAS  PubMed  Google Scholar 

  18. Skakkebaek, N.E., Berthelsen, J.G., Giwercman, A. & Muller, L. Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int. J. Androl. 10, 19–28 (1987).

    Article  CAS  PubMed  Google Scholar 

  19. Wilson, J.D. The role of androgens in male gender role behavior. Endocr. Rev. 20, 726–737 (1999).

    Article  CAS  PubMed  Google Scholar 

  20. Gosden, R. Ovulation 1: oocyte development through life in Gametes – The oocyte (eds Grudzinskas, J. & Yovich, J.) 119–149 (Cambridge Univ. Press, Cambridge, 1995).

  21. Gougeon, A. Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr. Rev. 17, 121–154 (1996).

    Article  CAS  PubMed  Google Scholar 

  22. Hardy, K., Wright, C.S., Franks, S. & Winston, R.M. In vitro maturation of oocytes. Br. Med. Bull. 56, 588–602 (2000).

    Article  CAS  PubMed  Google Scholar 

  23. Wehr, T.A. Photoperiodism in humans and other primates: evidence and implications. J. Biol. Rhythms 16, 348–364 (2001).

    Article  CAS  PubMed  Google Scholar 

  24. Rojansky, N., Brzezinski, A. & Schenker, J.G Seasonality in human reproduction: an update. Hum. Reprod. 7, 735–745 (1992).

    Article  CAS  PubMed  Google Scholar 

  25. Rojansky, N. et al. Seasonal variability in fertilization and embryo quality rates in women undergoing IVF. Fertil. Steril. 74, 476–481 (2000).

    Article  CAS  PubMed  Google Scholar 

  26. Jorgensen, N., Andersen, A.-G. & Eustache, F. Regional differences in semen quality in Europe. Hum. Reprod. 16, 1012–1019 (2001).

    Article  CAS  PubMed  Google Scholar 

  27. Lam, D.A. & Miron, J.A. The effects of temperature on human fertility. Demography 33, 291–305 (1996).

    Article  CAS  PubMed  Google Scholar 

  28. Mieusset, R. & Bujan, L. The potential of mild testicular heating as a safe, effective and rversible contraceptive method fro men. Int. J. Androl. 17, 186–191 (1994).

    Article  CAS  PubMed  Google Scholar 

  29. Setchell, B.P. The Parkes lecture. Heat and the testis. J. Reprod. Fertil. 114, 179–194 (1998).

    Article  CAS  PubMed  Google Scholar 

  30. Mieusset, R. & Bujan, L. Testicular heating and its possible contributions to male infertility: a review. Int. J. Androl. 18, 169–184 (1995).

    Article  CAS  PubMed  Google Scholar 

  31. Thonneau, P. Bujan, L. Multigner, L. & Mieusset, R. Occupational heat exposure and male fertility: a review. Hum. Reprod. 13, 2122–2125 (1998).

    Article  CAS  PubMed  Google Scholar 

  32. Bujan, L., Daudin, M., Charlet, J-P., Thonneau, P. & Mieusset, R. Increase in scrotal temperature in car drivers. Hum. Reprod. 15, 1355–1357 (2000).

    Article  CAS  PubMed  Google Scholar 

  33. Hjollund, N.H., Bonde, J.P., Jensen, T.K. & Olsen, J. Diurnal scrotal skin temperature and semen quality. The Danish first pregnancy planner study team. Int. J. Androl. 23, 309–318 (2000).

    Article  CAS  PubMed  Google Scholar 

  34. Figa-Talamanca, I., Cini, C. & Varricchio, G.C. Effects of prolonged autovehicle driving on male reproductive function: a study among taxi drivers. Am. J. Ind. Med. 30, 750–758 (1996).

    Article  CAS  PubMed  Google Scholar 

  35. Brindley, G.S. Deep scrotal temperature and the effect on it of clothing, air temperature, activity, posture and paraplegia. Br. J. Urol. 54, 49–55 (1982).

    Article  CAS  PubMed  Google Scholar 

  36. Hughes, E.G. & Brennan, B.G. Does smoking impair natural or assisted fecundity? Fertil. Steril. 66, 679–689 (1996).

    Article  CAS  PubMed  Google Scholar 

  37. Vine, M.F. Smoking and male reproduction: a review. Int. J. Androl. 19, 323–337 (1996).

    Article  CAS  PubMed  Google Scholar 

  38. Joesbury, K.A., Edirisinghe, W.R., Phillips, M.R. & Yovich, J.L. Evidence that male smoking affects the likelihood of a pregnancy following IVF treatment: application of the modified cumulative embryo score. Hum. Reprod. 13, 1506–1513 (1998).

    Article  CAS  PubMed  Google Scholar 

  39. Rubes, J. et al. Smoking cigarettes is associated with increased sperm disomy in teenage men. Fertil. Steril. 70, 715–723 (1998).

    Article  CAS  PubMed  Google Scholar 

  40. Zenzes, M.T., Bielecki, R. & Reed, T.E. Detection of benzo(a)pyrene diol epoxide-DNA adducts in sperm of men exposed to cigarette smoke. Fertil. Steril. 72, 330–335 (1999).

    Article  CAS  PubMed  Google Scholar 

  41. Jensen, T.K., Hjollund, N.H., Henriksen, T.B., Scheike, T. & Kolstad, H. Does moderate alcohol consumption affect fertility? Follow up study among couples planning first pregnancy. Br. Med. J. 317, 505–510 (1998).

    Article  CAS  Google Scholar 

  42. Juhl, M., Nyboe-Andersen, A.M., Gronbaek, M. & Olsen, J. Moderate alcohol consumption and waiting time to pregnancy. Hum. Reprod. 16, 2705–2709 (2001).

    Article  CAS  PubMed  Google Scholar 

  43. Bolumar, F., Olsen, J. & Boldsen, J. Smoking reduces fecundity: a European multicenter study on infertility and subfecundity. The European study group on infertility and subfecundity. Am. J. Epidemiol. 143, 578–587 (1996).

    Article  CAS  PubMed  Google Scholar 

  44. Buck, G.M., Sever, L.E., Batt, R.E. & Mendola, P. Life-style factors and female infertility. Epidemiology 8, 435–441 (1997).

    Article  CAS  PubMed  Google Scholar 

  45. Feichtinger, W., Papalambrou, K., Poehl, M., Krischker, U. & Neumann, K. Smoking and in vitro fertilization: a meta-analysis. J. Assist. Reprod. Genet. 14, 596–599 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Augood, C. Duckitt, K. & Templeton, A.A. Smoking and female infertility: a systematic review and meta-analysis. Hum. Reprod. 13, 1532–1529 (1998).

    Article  CAS  PubMed  Google Scholar 

  47. Klonoff-Cohen, H., Natarajan, L., Marrs, R. & Yee, B. Effects of female and male smoking on success rates of IVF and gamete intra-Fallopian transfer. Hum. Reprod. 16, 1382–1390 (2001).

    Article  CAS  PubMed  Google Scholar 

  48. Sebire, N.J. et al. Maternal obesity and pregnancy outcome: a study of 287, 213 pregnancies in London. Int. J. Obes. Relat. Disord. 25, 1175–1182 (2001).

    Article  CAS  Google Scholar 

  49. Holly, J.M.P., Smith, C.P. & Dunger, D.B Relationship between the fall in sex hormone-binding globulin and insulin-like growth factor binding protein-I. A synchronized approach to pubertal development? Clin. Endocrinol. 31, 277–284 (1989).

    Article  CAS  Google Scholar 

  50. Cunningham, M.J., Clifton, D.K. & Steiner, R.A. Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol. Reprod. 60, 216–222 (1999).

    Article  CAS  PubMed  Google Scholar 

  51. Bruning, J.C., Gautman, D. & Burks, D.J. Role of brain insulin receptor in control of body weight and reproduction. Science 289, 2122–2125 (2000).

    Article  CAS  PubMed  Google Scholar 

  52. Franks, S., Robinson, S. & Willis, D. Nutrition, insulin and polycystic ovary syndrome (review). Rev. Reprod. 1, 47–53 (1996).

    Article  CAS  PubMed  Google Scholar 

  53. Grinspoon, S., Gulick, T. & Askari, H. Serum leptin levels in women with anorexia nervosa. J. Clin. Endocrinol. Metab. 81, 3861–3863 (1996).

    CAS  PubMed  Google Scholar 

  54. Hamilton-Fairley, D., Kiddy, D., Watson, H. Paterson, C. & Franks, S. Association of moderate obesity with a poor pregnancy outcome in women with polycystic ovary syndrome treated with low dose gonadotrophin. Br. J. Obstet. Gynaecol. 99, 128–131 (1992).

    Article  CAS  PubMed  Google Scholar 

  55. Franks, S. Medical Progress Article: Polycystic ovary syndrome (review). N. Engl. J. Med. 333, 853–861 (1995).

    Article  CAS  PubMed  Google Scholar 

  56. Franks, S. et al. The genetic basis of polycystic ovary syndrome (review). Hum. Reprod. 12, 2641–2648 (1997).

    Article  CAS  PubMed  Google Scholar 

  57. Urbanek, M., Legro, R.S. & Driscoll, D.A. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc. Natl Acad. Sci. USA 96, 8573–8578 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Abbott, D., Dumesic, D. & Franks, S. Developmental origin of polycystic ovary syndrome. J. Endocrinol. (in the press).

  59. Dunaif, A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev. 18, 774–800 (1997).

    CAS  PubMed  Google Scholar 

  60. Tuvemo, T. & Proos, L.A. Girls adopted from developing countries: a group at risk of early pubertal development and short final height. Implications for health surveillance and treatment. Ann. Med. 25, 217–219 (1993).

    Article  CAS  PubMed  Google Scholar 

  61. Virdis R et al. Precocious puberty in girls adopted from developing countries. Arch. Dis. Child 78, 152–154 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Adair, L.S. Size at birth predicts age at menarche. Pediatrics 107, E59 (2001).

    Article  CAS  PubMed  Google Scholar 

  63. Krstevska-Konstantinova, M. et al. Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides. Hum. Reprod. 16, 1020–1026 (2001).

    Article  CAS  PubMed  Google Scholar 

  64. Birth weight symposium (editorials) Arch. Dis. Child Fetal Neonatal 86, F2–F8 (2002).

  65. Barker D.J.P. et al. Fetal nutrition and cardiovascular disease in later life. Lancet 341, 938–941 (1993).

    Article  CAS  PubMed  Google Scholar 

  66. Godfrey, K., Robinson, S., Barker, D.J.P., Osmond, C. & Cox, V. Maternal nutrition in early and late pregnancy in relation to placental and fetal growth. Br. Med. J. 312, 410–414 (1996).

    Article  CAS  Google Scholar 

  67. Fetal programming: influences on development and disease in later life. (eds O'Brien P.M.S., Wheeler, T., Barker, D.J.P.) (Royal College of Obstetricians & Gynaecologists Press, London 1999).

  68. Stephenson, T. & Symonds, M.E. Maternal nutrition as a determinant of birth weight. Arch. Dis. Child Fetal Neonatal 86, F4–F6 (2002).

    Article  CAS  Google Scholar 

  69. Jaquet, D., Leger, J., Chevenne, D., Czernichow, P. & Levy-Marchal, C. Intrauterine growth retardation predisposes to insulin resistance but not to hyperandrogenism in young women. J. Clin. Endocrinol. Metab. 84, 3945–3949 (1999).

    Article  CAS  PubMed  Google Scholar 

  70. Grumbach, M.M. & Auchus, R.J. Estrogen: consequences and implications of human mutations in synthesis and action. J. Clin. Endocrinol. 84, 4677–4694 (1999).

    CAS  Google Scholar 

  71. Cooke, P.S., Heine, P.A., Taylor, J.A. & Lubahn, D.B. The role of estrogen and estrogen receptor-α in male adipose tissue. Mol. Cell. Endocrinol. 178, 147–154 (2001).

    Article  CAS  PubMed  Google Scholar 

  72. Simpson, E.R. et al. Aromatase — a brief overview. Annu. Rev. Physiol. 64, 93–127 (2002).

    Article  CAS  PubMed  Google Scholar 

  73. Francois, I., de Zegher, F., Spiessens, C. D'Hooghe, T. & Vanderschueren, D. Low birth weight and subsequent male subfertility. Pediatr. Res. 42, 899–901 (1997).

    Article  CAS  PubMed  Google Scholar 

  74. Olsen, J. et al. Birthweight and semen characteristics. Int. J. Androl. 23, 230–235 (2000).

    Article  CAS  PubMed  Google Scholar 

  75. Ozturk, O., Armstrong, K., Bhttacharya, S. & Templeton, A.A. Fetal antecedents of male factor sub-fertility: how important is birthweight? Hum. Reprod. 16, 2238–2241 (2001).

    Article  CAS  PubMed  Google Scholar 

  76. Francois, I., van Helvoirt, M. & de Zegher, F. Male pseudohermaphroditism related to complications at conception, in early pregnancy or in prenatal growth. Horm. Res. 51, 91–95 (1999).

    CAS  PubMed  Google Scholar 

  77. Ibanez, L. Potau, N. Enrique, G. & de Zegher, F. Reduced uterine and ovarian size in adolescent girls born small for gestational age. Pediatr. Res. 47, 575–577 (2000).

    Article  CAS  PubMed  Google Scholar 

  78. Jensen T.K. et al. Adult and prenatal exposures to tobacco smoke as risk indicators of fertility among 430 Danish couples. Am. J. Epidemiol. 148, 992–997 (1998).

    Article  CAS  PubMed  Google Scholar 

  79. Phillips, D.H. Polycyclic aromatic hydrocarbons in the diet. Mut. Res. 443, 139–147 (1999).

    Article  CAS  Google Scholar 

  80. Harlow, B.L. & Signorello, L.B. Factors associated with early menopause. Maturitas 35, 3–9 (2000).

    Article  CAS  PubMed  Google Scholar 

  81. Matikainen, T.M. et al. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nature Genet. 28, 355–360 (2001).

    Article  CAS  PubMed  Google Scholar 

  82. Matikainen, T.M. et al. Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells. Endocrinology 143, 615–620 (2002).

    Article  CAS  PubMed  Google Scholar 

  83. Mably, T.A., Bjerke, D.L., Moore, R.W., Gendron-Fitzpatrick, A. & Peterson, R.E. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects on spermatogenesis and reproductive capability. Toxicol. Appl. Pharmacol. 114, 118–126 (1992).

    Article  CAS  PubMed  Google Scholar 

  84. Cocco, P. On the rumours about silent spring. Review of the scientific evidence linking occupational and environmental pesticide exposure to endocrine disruption health effects. Cad. Saude Publica 18, 379–402 (2002).

    Article  PubMed  Google Scholar 

  85. Whorton, D. & Foliart, D. DBCP: eleven years later. Reprod. Toxicol. 2, 155–161 (1988).

    Article  CAS  PubMed  Google Scholar 

  86. Garcia-Rodriguez, J. et al. Exposure to pesticides and cryptorchidism: geographical evidence of a possible association. Environ. Health Perspect. 104, 1090–1095 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  87. Weidner, I.S. Moller, H., Jensen, T.K. & Skakkebaek, N.E. Cryptorchidism and hypospadias in sons of gardeners and farmers. Environ Health Perspect. 106, 793–796 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Oliva, A., Spira, A. & Multigner, L. Contribution of environmental factors to the risk of male infertility. Hum. Reprod. 16, 1768–1776 (2001).

    Article  CAS  PubMed  Google Scholar 

  89. Larsen, S.B., Joffe, M. & Bonde, J.P. Time to pregnancy and exposure to pesticides in Danish farmers. Asclepios study group. Occup. Environ. Med. 55, 278–283 (1998).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Welch, L.S., Schrader, S.M., Turner, T.W. & Cullen, M.R. Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction. Am. J. Ind. Med. 14, 509–526 (1988).

    Article  CAS  PubMed  Google Scholar 

  91. Haavisto, T. et al. Prenatal testosterone and LH levels in male rats exposed during pregnancy to 2,3,7,8-tetrachlorodibenzo-p-dixin and diethylstilbestrol. Mol. Cell. Endocrinol. 178, 169–179 (2001).

    Article  CAS  PubMed  Google Scholar 

  92. Williams, K. et al. Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen:oestrogen balance and assessment of the relevance to man. Hum. Reprod. Update 7, 236–247 (2001).

    Article  CAS  PubMed  Google Scholar 

  93. Andersson, A.-M. & Skakkebaek, N.E. Exposure to exogenous estrogens in food: possible impact on human development and health. Eur. J. Endocrinol. 140, 477–485 (1999).

    Article  CAS  PubMed  Google Scholar 

  94. Kester, M.H.A. et al. Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141, 1897–1900 (2000).

    Article  CAS  PubMed  Google Scholar 

  95. Kester M.H.A. et al. Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters. J. Clin. Endocrinol. Metab. 87, 1142–1150 (2002).

    Article  CAS  PubMed  Google Scholar 

  96. Swerdlow, A.J., De Stavola, B.L., Swanwick, M.A. & Maconochie, N.E.S. Risks of breast and testicular cancers in young adult twins in England and Wales: evidence on prenatal and genetic aetiology. Lancet 350, 1723–1728 (1997).

    Article  CAS  PubMed  Google Scholar 

  97. Zheng, W. et al. Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 10, 89–94 (2001).

    PubMed  Google Scholar 

  98. Li, L-H., Jester, W.F. Jr, Laslett, A.L & Orth, J.M. A single dose of Di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces Sertoli cell proliferation and decreases cyclin D2 expression. Toxicol. Appl. Pharmacol. 166, 222–229 (2000).

    Article  CAS  PubMed  Google Scholar 

  99. Mylchreest, E., Wallace, D.G, Cattley, R.C. & Foster, P.M.D. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation. Toxicol. Sci. 55, 143–151 (2000).

    Article  CAS  PubMed  Google Scholar 

  100. Parks, L.G. et al. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol. Sci. 58, 339–349 (2000).

    Article  CAS  PubMed  Google Scholar 

  101. Blount, B.C. et al. Levels of seven urinary phthalate metabolites in a human reference population. Environ. Health Perspect. 108, 979–982 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Longnecker, M.P., Klebanpoff, M.A., Zhou, H. & Brock, J.W. Association between maternal serum concentration of the DDT metabolite DDE and preterm and small-for-gestational-age babies at birth. Lancet 358, 110–114 (2001).

    Article  CAS  PubMed  Google Scholar 

  103. Longnecker, M.P. et al. Maternal serum level of 1,1-dichloro-2,2-bis(p-chlrorophenyl)ethylene and risk of cryptorchdisim, hypospadias and polythelia among male offspring. Am. J. Epidemiol. 155, 313–322 (2002).

    Article  PubMed  Google Scholar 

  104. Kelce, W.R. et al. Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375, 581–585 (1995).

    Article  CAS  PubMed  Google Scholar 

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Sharpe, R., Franks, S. Environment, lifestyle and infertility — an inter-generational issue. Nat Med 8 (Suppl 10), S33–S40 (2002). https://doi.org/10.1038/nm-fertilityS33

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