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Origins of the TH1-TH2 model: a personal perspective

Nature Immunology volume 7, pages 539–541 (2006)Cite this article

Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to the T helper type 1–T helper type 2 hypothesis.

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Figure 1: The principal stimulatory and inhibitory interactions between TH1 and TH2 cells, both directly and through their effector functions.

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Acknowledgements

I thank T. Mosmann for his role in the work recollected here; colleagues at DNAX and at other institutions for contributions to the development of the TH1-TH2 hypothesis; and S. Coffman, F. Barrat, E. Hessel and H. Kanzler for comments on the manuscript.

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  1. Dynavax Technologies, Berkeley, 94710, California, USA

    Robert L Coffman

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Coffman, R. Origins of the TH1-TH2 model: a personal perspective. Nat Immunol 7, 539–541 (2006). https://doi.org/10.1038/ni0606-539

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