The invariant chain CD74 prevents the loading of peptides derived from endogenously synthesized proteins onto major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum. CD74 is now shown to serve a similar function for some MHC class I molecules.
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Duan, F., Srivastava, P. An invariant road to cross-presentation. Nat Immunol 13, 207–208 (2012). https://doi.org/10.1038/ni.2235
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DOI: https://doi.org/10.1038/ni.2235
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