Cancer cells have a raised cellular metabolism, including increased protein biosynthesis. Three new studies now show that the oncoprotein Myc, known to drive cell division, also enhances ribosomal RNA synthesis by RNA polymerase I in addition to controlling RNA polymerase II- and III-regulated gene transcription. This suggests that Myc promotes the generation of crucial components of a functional ribosome.
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References
Sherr, C. J. Cell 116, 235–246 (2004).
Stocker, H. & Hafen, E. Curr. Opin. Genet. Dev. 10, 529–535 (2000).
White, R. J. Nature Rev. Mol. Cell Biol. 6, 69–78 (2005).
Grummt, I. Genes Dev. 17, 1691–1702 (2003).
Arabi, A. et al. Nature Cell Biol. 7, 302–309 (2005).
Grandori, C. et al. Nature Cell Biol. 7, 310–317 (2005).
Grewal, S. S., Li, L., Orian, A., Eisenman, R. N. & Edgar, B. A. Nature Cell Biol. 7, 294–301 (2005).
Moss, T. Curr. Opin. Genet. Dev. 14, 210–217 (2004).
Levens, D. L. Genes Dev. 17, 1071–1077 (2003).
Grandori, C., Cowley, S. M., James, L. P. & Eisenman, R. N. Annu. Rev. Cell Dev. Biol. 16, 653–699 (2000).
Wilson, A. et al. Genes Dev. 18, 2747–2763 (2004).
Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N. & Gallant, P. Cell 98, 779–790 (1999).
Schuhmacher, M. et al. Curr. Biol. 9, 1255–1258 (1999).
Schlosser, I. et al. Nucleic Acids Res. 31, 6148–6156 (2003).
Poortinga, G. et al. EMBO J. 23, 3325–3335 (2004).
Eisenman, R. N. Genes Dev. 15, 2023–2030 (2001).
Frank, S. R. et al. EMBO Rep. 4, 575–580 (2003).
Arabi, A., Rustum, C., Hallberg, E. & Wright, A. P. J. Cell Sci. 116, 1707–1717 (2003).
von der Lehr, N. et al. Mol. Cell 11, 1189–1200 (2003).
Kim, S. Y., Herbst, A., Tworkowski, K. A., Salghetti, S. E. & Tansey, W. P. Mol. Cell 11, 1177–1188 (2003).
Welcker, M., Orian, A., Grim, J. A., Eisenman, R. N. & Clurman, B. E. Curr. Biol. 14, 1852–1857 (2004).
Trumpp, A. et al. Nature 414, 768–773 (2001).
Zhao, J., Yuan, X., Frodin, M. & Grummt, I. Mol. Cell 11, 405–413 (2003).
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Oskarsson, T., Trumpp, A. The Myc trilogy: lord of RNA polymerases. Nat Cell Biol 7, 215–217 (2005). https://doi.org/10.1038/ncb0305-215
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DOI: https://doi.org/10.1038/ncb0305-215
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