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  • Letter to the Editor
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Comment on ‘Integrative genomic profiling of human prostate cancer’

Leukemia volume 24, pages 1970–1972 (2010)Cite this article

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With great interest we read the recent publication in Cancer Cell by Taylor et al.1 who reported on an integrative genomic profiling approach that resulted in the discovery of a previously unrecognized deletion in human prostate cancer encompassing chromosome band 3p14. Found to be associated with the TMPRSS2-ERG fusion, this aberration comprised only eight genes and could be further narrowed down by inspection of additional cases and association with gene expression data to three genes, FOXP1, RYBP and SHQ1.

In accordance to the findings by Taylor et al.1 in prostate cancer, parallel analysis of gene expression showed a marked downregulation of the deleted genes with the most pronounced gene dosage effects for RYBP (Ring and YY1 binding protein) and SHQ1 (Figure 1b), and none of the 3p deleted cases harbored FOXP1 mutations in the remaining allele (unpublished data). Furthermore, supervised analysis comparing the 3p14.1-p13 deleted cases with other cytogenetically normal acute myeloid leukemias showed a characteristic gene expression profile, thereby further pointing to a distinct biology underlying these cases.

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Figure 1

References

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Authors and Affiliations

  1. Department of Internal Medicine III, University of Ulm, Ulm, Germany

    L Bullinger, J Krönke, V Gaidzik, H Döhner & K Döhner

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  1. L Bullinger
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  2. J Krönke
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Correspondence to K Döhner.

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Bullinger, L., Krönke, J., Gaidzik, V. et al. Comment on ‘Integrative genomic profiling of human prostate cancer’. Leukemia 24, 1970–1972 (2010). https://doi.org/10.1038/leu.2010.194

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