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Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum

Journal of Perinatology volume 35, pages 788–792 (2015)Cite this article

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Abstract

Objective:

To determine serum thiol-disulfide homeostasis in hyperemesis gravidarum.

Study Design:

Twenty-six pregnant women with hyperemesis gravidarum and 37 healthy pregnant women were included in the study. Native thiol, disulfide and total thiol concentrations were measured with a novel automated method.

Results:

Serum disulfide levels were 15.68±4.41 μmol l−1 in the hyperemesis gravidarum group and 13.49±2.81 μmol l−1 in the healthy group (P=0.031). Native thiol levels were 213.86±26.29 μmol l−1 in the hyperemesis gravidarum group and 232.18±19.21 μmol l−1 in healthy group (P=0.004), and total thiol levels were 245.23±28.58 μmol l−1 in the hyperemesis gravidarum group and 259.17±19.94 μmol l−1 in the healthy group (P=0.038).

Conclusion:

Native and total thiol were deficient in the hyperemesis gravidarum group and this deficiency was correlated with the severity of the disease. The thiol-disulfide balance has shifted to the oxidative side. This metabolic disturbance may have a role in the pathogenesis of hyperemesis gravidarum.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey

    M Ergin, S Neselioglu & O Erel

  2. Department of Obstetrics and Gynecology, Dr Nafiz Körez Sincan State Hospital, Ankara, Turkey

    B D Cendek

  3. Department of Obstetrics and Gynecology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey

    A F Avsar

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  1. M Ergin
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  2. B D Cendek
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  4. A F Avsar
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  5. O Erel
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Correspondence to M Ergin.

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Ergin, M., Cendek, B., Neselioglu, S. et al. Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum. J Perinatol 35, 788–792 (2015). https://doi.org/10.1038/jp.2015.81

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