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Probiotics supplementation increases intestinal blood flow velocity in extremely low birth weight preterm infants

Journal of Perinatology volume 33, pages 40–44 (2013)Cite this article

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Abstract

Objective:

To determine whether probiotics supplementation affects intestinal blood flow velocity in extremely low birth weight neonates.

Study Design:

In this randomized, double-blind, placebo-controlled study, probiotics were added to the first enteral feeding and continued until discharge or 34 weeks postmenstrual age. Pulsed Doppler was used to measure preprandial and postprandial (at 30 and 60 min) time-averaged mean velocity (TAMV), peak systolic velocity (PSV) and end diastolic velocity (EDV) during the second week of life after ⩾7 days of probiotics supplementation.

Result:

A total of 31 infants were studied, 15 were randomized to the probiotic and 16 to the placebo groups. There was a significant postprandial increase in TAMV for the probiotic vs the placebo group (P=0.035), with PSV and EDV showing a trend. Demographic and clinical variables were similar between the groups.

Conclusion:

Probiotics administration significantly increases postprandial intestinal blood flow in extremely low birth weight preterm neonates when compared with the placebo group.

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References

  1. Food and Agriculture Organization of the United Nations; World Health Organization. Guidelines for the evaluations of probiotics in food: joint FAO/WHO Working Group report on drafting guidelines for the evaluation of probiotics in food. Available at: ftp://ftp.fao.org/es/esn/food/wgreport2.pdf, accessed 1 March 2011.

  2. Food and Agriculture organization of the United Nations; World Health Organization. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria: report of a joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic bacteria. Available at: www.who.int/foodsafety/publications/fs_management/en/probiotics.pdf, accesssed 1 March 2011.

  3. Council for Agricultural Science and Technology. Probiotics: Their potential to Impact Human Health. Council for Agricultural Science and Technology: Ames, IA, 2007. Available at: www.cast-science.org/websiteUploads/publicationPDFs/CAST%20Probiotics%20Issue%Paper%20FINAL144.pdf, accessed 1 March 2011.

  4. Thomas DW, Greer FR . Probiotics and prebiotics in pediatrics. Pediatrics 20; 126 (6): 1217–1231.

    Article  Google Scholar 

  5. Martin CR, Walker WA . Probiotics: role in pathophysiology and prevention in necrotizing enterocolitis. Semin Perinatol 2008; 32: 127–137.

    Article  Google Scholar 

  6. Deshpande G, Rao S, Patole S, Bulsara M . Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010; 125 (5): 921–930.

    Article  Google Scholar 

  7. Broadley KJ, Akhtar AM, Herbert AA, Fehler M, Jones EM, Davies WE et al. Effects of dietary amines on the gut and its vasculature. Br J Nutr 2009; 101 (11): 1645–1652.

    Article  CAS  Google Scholar 

  8. Herbert AA, Kidd EJ, Broadley KJ . Dietary trace amine-dependent vasoconstriction in porcine coronary artery. Br J Pharmacol 2008; 155 (4): 525–534.

    Article  CAS  Google Scholar 

  9. Maruyama K, Koizumi T, Tomomasa T, Morikawa A . Intestinal blood flow velocity in uncomplicated preterm infants during the early neonatal period. Pediatr Radiol 1999; 29: 472–477.

    Article  CAS  Google Scholar 

  10. Fang S, Kempley ST, Gamsu HR . Prediction of early tolerance to enteral feeding in preterm infants by measurement of superior mesenteric artery blood flow velocity. Arch Dis Child Fetal Neonat Ed 2001; 85: F42–F45.

    Article  CAS  Google Scholar 

  11. Al-Hosni M, Duenas M, Hawk M, Stewart LA, Borghese RA, Cahoon M et al. Probiotics-supplemented feeding in extremely low-birth-weight infants. J Perinatol; e-pub ahead of print 5 May 2011.

  12. Carver JD, Saste M, Sosa R, Zaritt J, Kuchan M, Barness LA . The effects of dietary nucleotides on intestinal blood flow in preterm infants. Pediatr Res 2002; 52: 425–429.

    Article  CAS  Google Scholar 

  13. Lane AJP, Coombs RC, Evans DH, Levin RJ . Effect of feed interval and feed type on splanchnic haemodynamics. Arch Dis Child Fetal Neonatal Ed 1998; 79: F49–F53.

    Article  CAS  Google Scholar 

  14. Robel-Tillig E, Knupfer M, Pulzer F, Vogtmann C . Blood flow parameters of the superior mesenteric artery as an early predictor of intestinal dysmotility in preterm infants. Pediatr Radiol 2004; 34: 958–962.

    Article  Google Scholar 

  15. Havranek T, Thompson Z, Carver JD . Factors that influence mesenteric artery blood flow velocity in newborn preterm infants. J Perinatol 2006; 26: 493–497.

    Article  CAS  Google Scholar 

  16. Martinussen M, Brubakk AM, Vik T, Yao AC . Mesenteric blood flow velocity and its relation to transitional circulatory adaptation in appropriate for gestational age preterm infants. Pediatr Res 1996; 39: 275–280.

    Article  CAS  Google Scholar 

  17. Coombs RC, Morgan MEI, Durbin GM, Booth IW, McNeish AS . Doppler assessment of human neonatal gut blood flow velocities: postnatal adaptation and response to feeds. J Pediatr Gastroenterol Nutr 1992; 15: 6–12.

    Article  CAS  Google Scholar 

  18. Yanowitz TD, Yao AC, Pettigrew KD, Werner JC, Oh W, Stonestreet BS . Postnatal hemodynamic changes in very-low-birthweight infants. J Appl Physiol 1999; 87: 370–380.

    Article  CAS  Google Scholar 

  19. Hoecker C, Nelle M, Poeschl J, Beedgen B, Linderkamp O . Caffeine impairs cerebral and intestinal blood flow velocity in preterm infants. Pediatrics 2002; 109: 784–787.

    Article  Google Scholar 

  20. Soraisham AS, Elliott D, Amin H . Effect of single loading dose of intravenous caffeine infusion on superior mesenteric artery blood flow velocities in preterm infants. J Paediatr Child Health 2008; 44 (3): 119–121.

    Article  Google Scholar 

  21. Lane AJ, Coombs RC, Evans DH, Levin RJ . Effect of caffeine on neonatal splanchnic blood flow. Arch Dis Child Fetal Neonatal Ed 1999; 80 (2): F128–F129.

    Article  CAS  Google Scholar 

  22. Kempley ST, Murdoch E . Splanchnic haemodynamic disturbances in perinatal sepsis. Arch Dis Child fetal Neonatal Ed 2000; 83: F139–F142.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Cardinal Glennon Children's Medical Center, Saint Louis University School of Medicine, Saint Louis, MO, USA

    T Havranek, M Al-Hosni & E Armbrecht

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  1. T Havranek
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  2. M Al-Hosni
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  3. E Armbrecht
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Correspondence to T Havranek.

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Havranek, T., Al-Hosni, M. & Armbrecht, E. Probiotics supplementation increases intestinal blood flow velocity in extremely low birth weight preterm infants. J Perinatol 33, 40–44 (2013). https://doi.org/10.1038/jp.2012.37

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