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Pediatric Transplants

Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease

Bone Marrow Transplantation volume 46, pages 529–538 (2011)Cite this article

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Abstract

The objective of this study was to assess the incidence, risk factors, outcome and impact on OS of pericardial effusion (PEF) in a cohort of 156 pediatric SCT recipients. The mean age was 8.15±6.25 years. In all, 74% of the patients had malignant disease and 35% of the patients received autologous stem cell grafts. Twenty-three subjects developed effusion at 2.75±3.54 months after SCT. The overall probability of developing a PEF after SCT was 16.9%. In the multivariate analysis of risk factors associated with time to PEF, increased age, allogeneic risk status and conditioning type, were all significant factors. In a multivariate analysis of time to death, PEF, CMV status and risk status were all independent risk factors. PEF, however, had the highest HR of 3.334. Of the 23 patients with PEF, 19 died (82.6%); however, none died as a direct result of pericardial tamponade. In summary, our results suggest that PEF is a significant risk factor for post transplant mortality. These results suggest a need for more frequent evaluation and monitoring for development of PEF. Studies are needed to determine the etiology of, and new therapeutic strategies for, PEF in the post-SCT population.

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Acknowledgements

This work was supported in part by grants from the Pediatric Cancer Research Foundation, Brittany Baron Fund, Sonia Scaramella Fund, Bevanmar Foundation, Paul Luisi Foundation, Dreaming for Discovery and Cure Fund, and the Marisa Fund.

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Authors and Affiliations

  1. Department of Pediatrics, Medicine and Pathology, Morgan Stanley Children's Hospital of New York-Presbyterian, Columbia University, New York, NY, USA

    M Neier, C Kleinman, L Baldinger, M Bhatia, E Silver, C van de Ven, E Morris, P Satwani, D George, J Garvin, M B Bradley & M S Cairo

  2. Department of Biostatistics, Columbia University, New York, NY, USA

    Z Jin

  3. Department of Pathology, Columbia University, New York, NY, USA

    J Schwartz & M S Cairo

  4. Department of Medicine, Columbia University, New York, NY, USA

    M S Cairo

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  1. M Neier
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  3. C Kleinman
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  4. L Baldinger
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  6. E Silver
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  7. C van de Ven
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  9. P Satwani
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  10. D George
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  12. M B Bradley
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  13. J Schwartz
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  14. M S Cairo
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Correspondence to M S Cairo.

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This work was presented in part at the American Society of Pediatric Hematology/Oncology, Toronto, Canada, May 2007 and American Society of Blood and Marrow Transplantation, San Diego, CA, February 2008.

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Neier, M., Jin, Z., Kleinman, C. et al. Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease. Bone Marrow Transplant 46, 529–538 (2011). https://doi.org/10.1038/bmt.2010.149

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