At the beginning of this month, Stanley Prusiner of the University of California, San Francisco, was awarded the Nobel Prize in Physiology or Medicine for his work on the infectious agent that causes spongiform encephalopathies _ the prion. His ‘protein-only’ theory now has many advocates, and the advances that have been made, the questions that remain and the ways in which these could be addressed are discussed in this feature.
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References
Weissmann, C. Nature 349, 569(1991).
Riek, R., Hornemann, S., Wider, G., Glockshuber, R. & Wuthrich, K. FEBS Lett. 413, 282–288 (1997).
Stahl, N. et al. in Prion Diseases of Humans and Animals (eds Prusiner, S., Collinge, J., Powell, J. & Anderton, B.) 361-379 (Ellis Horwood, New York, 1992).
Kellings, K., Meyer, N., Mirenda, C., Prusiner, S. B. & Riesner, D. J. Gen. Virol. 73, 1025–1029 (1992).
Bessen, R. A.et al. Nature 375, 698–700 (1995).
Collinge, J.et al. Lancet 346, 569–570 (1995).
Riesner, D.et al. J. Virol. 70, 1714–1722 (1996).
Prusiner, S. B.et al. Cell 63, 673–686 (1990).
Kempe, M., Glad, M. & Mosbach, K. J. Mol. Recog. 8, 35–39 (1995).
Bessen, R. A. & Marsh, R. F. J. Virol. 68, 7859–7868 (1994).
Bruce, M. E.et al. Nature 389, 498–501 (1997).
Hill, A. F.et al. Nature 389, 448–450 (1997).
Collinge, J., Sidle, K. C., Meads, J., Ironside, J. & Hill, A. F. Nature 383, 685–690 (1996).
Aguzzi, A. & Weissmann, C. Nature 383, 666–667 (1996).
Whittington, M. A.et al. Nature Genet. 9, 197–201 (1995).
Büeler, H. R.et al. Nature 356, 577–582 (1992).
Tobler, I.et al. Nature 380, 639–642 (1996).
Sakaguchi, S.et al. Nature 380, 528–531 (1996).
Telling, G. C.et al. Cell 83, 79–90 (1995).
Wickner, R. B. & Masison, D. C. Curr. Top. Microbiol. Immunol. 207, 147–160 (1996).
Brandner, S.et al. Nature 379, 339–343 (1996).
Raeber, A. J.et al. EMBO J. 16, 6057–6065 (1997).
Brown, D. R., Schmidt, B. & Kretzschmar, H. A. Nature 380, 345–347 (1996).
Hill, A. F., Zeidler, M., Ironside, J. & Collinge, J. Lancet 349, 99(1997).
Kimberlin, R. H. & Walker, C. A. Virus Res. 12, 213–220 (1989).
Blaettler, T.et al. Nature 389, 69–73 (1997).
Kimberlin, R. H. & Walker, C. A. J. Gen. Virol. 51, 183–187 (1980).
Brandner, S.et al. Proc. Natl Acad. Sci. USA 93, 13148–13151 (1996).
Prusiner, S. B. Science 216, 136–144 (1982).
Oesch, B.et al. Cell 40, 735–746 (1985).
Basler, K.et al. Cell 46, 417–428 (1986).
Hsiao, K.et al. Nature 338, 342–345 (1989).
Büeler, H. R.et al. Cell 73, 1339–1347 (1993).
Telling, G. C.et al. Genes Dev. 10, 1736–1750 (1996).
Brown, P., Goldfarb, L. G. & Gajdusek, D. C. Lancet 337, 1019–1022 (1991).
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Aguzzi, A., Weissmann, C. Prion research: the next frontiers. Nature 389, 795–798 (1997). https://doi.org/10.1038/39758
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DOI: https://doi.org/10.1038/39758
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