Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

New-age drug meets resistance

A new sort of anticancer drug, designed to suppress the wayward protein that causes a type of leukaemia, is under the spotlight. Biological detective work has now revealed how this cancer becomes resistant to the drug.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The progression of chronic myeloid leukaemia (CML).

References

  1. Druker, B. J. et al. New Engl. J. Med. 344, 1031–1037 (2001).

    CAS  PubMed  Google Scholar 

  2. Druker, B. J. et al. New Engl. J. Med. 344, 1038–1042 (2001).

    CAS  PubMed  Google Scholar 

  3. Gorre, M. E. et al. Science 21 June 2001 (10.1126/science.1062538).

  4. Konopka, J. B., Watanabe, S. M. & Witte, O. N. Cell 37, 1035–1042 (1984).

    CAS  PubMed  Google Scholar 

  5. McCormick, F. Curr. Opin. Biotechnol. 11, 593–597 (2000).

    CAS  PubMed  Google Scholar 

  6. Allegra, C. & Grem, J. L. in Cancer: Principles and Practice of Oncology (eds DeVita, V. T., Hellman, S. & Rosenberg, S. A.) 432–448 (Lippincott-Raven, Philadelphia, 1997).

    Google Scholar 

  7. Melnick, A. & Licht, J. D. Blood 93, 3167–3215 (1999).

    CAS  PubMed  Google Scholar 

  8. Huang, M. E. et al. Blood 72, 567–572 (1988).

    CAS  PubMed  Google Scholar 

  9. Gambacorti-Passerini, C. et al. Br. J. Haematol. 112, 972–974 (2001).

    CAS  PubMed  Google Scholar 

  10. Gray, J. W. & Collins, C. Carcinogenesis 21, 443–452 (2000).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Frank McCormick.

Rights and permissions

Reprints and permissions

About this article

Cite this article

McCormick, F. New-age drug meets resistance. Nature 412, 281–282 (2001). https://doi.org/10.1038/35085665

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35085665

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing