A new sort of anticancer drug, designed to suppress the wayward protein that causes a type of leukaemia, is under the spotlight. Biological detective work has now revealed how this cancer becomes resistant to the drug.
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References
Druker, B. J. et al. New Engl. J. Med. 344, 1031–1037 (2001).
Druker, B. J. et al. New Engl. J. Med. 344, 1038–1042 (2001).
Gorre, M. E. et al. Science 21 June 2001 (10.1126/science.1062538).
Konopka, J. B., Watanabe, S. M. & Witte, O. N. Cell 37, 1035–1042 (1984).
McCormick, F. Curr. Opin. Biotechnol. 11, 593–597 (2000).
Allegra, C. & Grem, J. L. in Cancer: Principles and Practice of Oncology (eds DeVita, V. T., Hellman, S. & Rosenberg, S. A.) 432–448 (Lippincott-Raven, Philadelphia, 1997).
Melnick, A. & Licht, J. D. Blood 93, 3167–3215 (1999).
Huang, M. E. et al. Blood 72, 567–572 (1988).
Gambacorti-Passerini, C. et al. Br. J. Haematol. 112, 972–974 (2001).
Gray, J. W. & Collins, C. Carcinogenesis 21, 443–452 (2000).
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McCormick, F. New-age drug meets resistance. Nature 412, 281–282 (2001). https://doi.org/10.1038/35085665
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DOI: https://doi.org/10.1038/35085665
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