Abstract
Positron emission tomography (PET) is now regularly used in the diagnosis and staging of cancer. These uses and its ability to monitor treatment response would be aided by the development of imaging agents that can be used to measure tissue and tumor proliferation. We have developed and tested [F-18]FLT (3'-deoxy-3'-fluorothymidine); it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects.
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Acknowledgements
This work was supported in part by Grant CA 39566 from the National Cancer Institute.
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Shields, A., Grierson, J., Dohmen, B. et al. Imaging proliferation in vivo with [F-18]FLT and positron emission tomography. Nat Med 4, 1334–1336 (1998). https://doi.org/10.1038/3337
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DOI: https://doi.org/10.1038/3337