Abstract
The frequency of α+-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria endemicity throughout Melanesia, supporting the hypothesis that protection against this parasitic disease is the major factor responsible for the high frequencies of haemoglobinopathies in many parts of the world.
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Flint, J., Hill, A., Bowden, D. et al. High frequencies of α-thalassaemia are the result of natural selection by malaria. Nature 321, 744–750 (1986). https://doi.org/10.1038/321744a0
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DOI: https://doi.org/10.1038/321744a0
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