Abstract
T-cell receptor α- and β-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity. Expression of the transfected α- and β genes endowed the recipient cell with the specificity of the donor cell.
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DembiĆ, Z., Haas, W., Weiss, S. et al. Transfer of specificity by murine α and β T-cell receptor genes. Nature 320, 232–238 (1986). https://doi.org/10.1038/320232a0
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DOI: https://doi.org/10.1038/320232a0
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