Abstract
The 17XNL strain of Plasmodium yoelii induces a highly effective and permanent T-cell dependent immunity in mice of the CBA strain1–3; the lethal variant P. yoelii 17XL and P. berghei (ANKA) fail to activate an effective immune response in the same host2–4. These differences in immunogenicity are unexplained. We recently observed that in CBA/CaJ mice the intracellular blood stages of P. yoelii 17XNL were almost exclusively within reticulocytes whereas lethal P.yoelii 17XL and P. berghei (ANKA), at comparable stages of infection, were predominantly erythrocytic. Induction of a reticulocytosis converted the normally lethal P. yoelii 17XL infection into a nonlethal one, and reticulocytic P. yoelii was shown to be more immunogenic than the erythrocytic form. Since one of the differences between reticulocytes and erythrocytes that might have influenced the development of immunity was greater expression of MHC antigens of the former cell type5–7 we examined the expression of H–2K, H–2D and Ia on reticulocytes infected with P. yoelii 17XNL. These cells showed a very marked increase in H–2K and D antigen expression compared to normal reticulocytes or erythrocytes. No Ia was detected. Red blood cells (RBC) infected with lethal P. yoelii 17XL or P. berghei showed no increase in H–2K or H–2D antigen expression. Finally, the level of expression of H–2K on P. yoelii 17XNL parasitized red blood cells from different strains of mice correlated closely with the ability of these strains to control the infection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Jayawardena, A. N., Targett, G. A. T., Carter, R. L., Leuchars, E. & Davies, A. J. S. Immunology 32, 849–858 (1977).
Jayawardena, A. N. et al. Nature 258, 149–151 (1975).
Jayawardena, A. N. in Parasitic Diseases Vol. 1, The Immunology (ed. Mansfield, J. M.) 85–136 (Dekker, New York, 1981).
Weinbaum, F. I., Evans, C. B. & Tieglar, R. E. J. Immun. 116, 1280–1283 (1976).
Giphart, M. J. cited by Van Rood, J. J. et al. in MHC in Immunobiology (ed Doort) (Garland, New York, 1981).
Kourilsky, F. M., Silvestere, D., Levey, J. P., Dausset, J., Nicolai, M. G. & Senik, A. J. Immun. 106, 454–466 (1971).
Harris, R. & Zervas, J. D. Nature 221, 1062–1063 (1969).
Kitchen, S. F. Sth. med. J., Nashville 32, 679–685 (1939).
Bruce-Chwatt, L. J. Ann. Trop. Med. Parasit. 42, 101–102 (1948).
Garnham, P. C. C. Malaria Parasites and Other Haemosporidia (Blackwell, Oxford, 1966).
Kitchen, S. F. Am. J. Trop. Med. 18, 347–353 (1938).
Craik, R. Lancet i 1110–1112 (1920).
Viens, P., Chevalier, J. L., Sonea, S. & Yoelii, M. Can. J. Microbiol. 17, 257–261 (1971).
Ott, K. K. J. J. Protozool. 15, 365–369 (1968).
Zinkernagel, R. M. Curr. Top. Microbiol. Immun. 82, 113–138 (1978).
Klein, J. Biology of the Mouse Histocompatibility H-2 Complex (Springer, New York, 1975).
Winchester, R. J. et al. J. exp. Med. 148, 613–618 (1978).
Hammerling, G. J., Eichmann, K. & Sorg, C. in The Role of Products of the MHC in Immune Responses (eds Katz, D. H. & Benacerraf, B.) 417 (Academic, New York, 1976).
Geiduschek, J. B. & Singer, S. J. Cell, 16, 149–163 (1979).
Doherty, P. C., Blande, R. V. & Zinkernagel, R. M. Transplant Rev. 29, 88–124 (1976).
Shearer, G. M., Rehn, T. G. & Schmitt-Verhulst, A. M. Transplanto Rev. 29, 222–248 (1976).
Meruelo, D., Nimelstein, S. H., Jones, P. P., Lieberman, M. & McDevitt, H. O. J. exp. Med. 147, 470–487 (1978).
Emerson, S. G., Murphy, D. B. & Cone, R. E. J. exp. Med. 152, 783–795 (1980).
Jayawardena, A. N., Murphy, D. B., Janeway, C. A. & Gershon, R. K. J. Immun. 129, 377–381 (1982).
Gershon, R. K. in The Role of Products of the Histocompatibility Gene Complex in Immune Responses (eds Katz, D. H. & Benacerraf, B) 193–202 (Academic, New York, 1976).
Gershon, R. K. & Cantor, H. in Development of Host Defenses (eds Cooper, M. D. & Dayton, D. H.) 155–163 (Raven, New York, 1977).
Gershon, R. K. et al. J. exp. Med. 153, 1533–1546 (1981).
Playfair, J. H. L., DeSouza, J. B. & Cottrell, B. J. Immunology 32, 681–687 (1977).
Howard, R. J., Smith, P. M. & Mitchell, G. F. Ann. Trop. Med. Parasit. 72, 573–575 (1978).
Oi, V., Jones, P. P., Coding, J. W., Herzenberg, L. A. & Herzenberg, L. A. Curr. Top. Microbiol. Immun. 81, 115–129 (1978).
Loken, M. R. & Herzenberg, L. A. Ann. N.Y. Acad. Sci. 254, 163–171 (1975).
Herzenberg, L. A., Sweet, R. B. & Herzenberg, L. A. Sci. Am. 234, 108 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jayawardena, A., Mogil, R., Murphy, D. et al. Enhanced expression of H–2K and H–2D antigens on reticulocytes infected with Plasmodium yoelii. Nature 302, 623–626 (1983). https://doi.org/10.1038/302623a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/302623a0
This article is cited by
-
Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention
Scientific Reports (2018)
-
Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii
Malaria Journal (2012)
-
Predominance of infected reticulocytes in the peripheral blood of CD4+ T-cell-depleted mice chronically infected withPlasmodium chabaudi chabaudi
Parasitology Research (1994)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.