Abstract
The decrease in leptin induced by starvation causes immune suppression, further demonstrating that falling and rising leptin levels have major, and quite distinct, physiologic consequences.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zhang, Y. et al. Positional cloning of the mouse ob gene and its human homologue. Nature 372, 425– 432 (1994).
Montague, C.T. et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903– 908 (1997).
Chen, H. et al. Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491–495 ( 1996).
Clement, K. et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398 –401 (1998).
Halaas, J. Weight reducing effect of the plasma protein encoded by the obese gene. Science 269, 543–546 ( 1995).
Frederich, R.C. et al. Expression of ob mRNA and its encoded protein in rodents: Impact of nutrition and obesity. J. Clin. Invest. 96 , 1658–1663 (1995).
Boden, G., Chen, X., Mozzoli, M. & Ryan, I. Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81, 3419–3423 ( 1996).
Ahima, R.S. et al. Role of leptin in the neuroendocrine response to fasting. Nature 382, 250–252 (1996).
Flier, J.S. Clinical review 94: What's in a name? In search of leptin's physiologic role. J. Clin. Endocrinol. Metab. 83, 1407– 1413 (1998).
Lord, G.M. et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394, 897– 901 (1998).
Mandel, M.A. & Mahmoud, A.A. Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J. Immunol. 120, 1375–1377 (1978).
Zhang, F. et al. Crystal structure of the obese protein leptin-E100. Nature 387, 206–209 ( 1997).
Scrimshaw, N.S. & SanGiovanni, J.P. Synergism of nutrition, infection, and immunity: An overview. Am. J. Clin. Nutr. 66, 464S–477S ( 1997).
Chandra, R.K. Nutrition and the immune system: An introduction. Am. J. Clin. Nutr. 66, 460S–463S ( 1997).
Elmquist, J.K., Maratos-Flier, E., Saper, C.B. & Flier, J.S. Unraveling the central nervous system pathways underlying responses to leptin. Nature Neurosci. 1, 443– 448 (1998).
Flier, J.S. & Maratos-Flier, E. Obesity and the hypothalamus: Novel peptides for new pathways. Cell 92, 437–440 (1998).
Tecott, L.H., Sun, L.M. & Akana, S.F. Eating disorder and epilepsy in mice lacking 5-HT 2C serotonin receptors. Nature 374, 542–546 (1995).
Nonogaki, K., Strack, A.M., Dallman, M.F. & Tecott, L.H. Leptin-independent hyperphagia and type 2 diabetes in serotonin 5-HT 2C receptor mutant mice. Nature Med. 4, 1152–1156 (1998).
Seeley, R.J. et al. Melanocortin receptors in leptin effects [letter]. Nature 390, 349 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Flier, J. Lowered leptin slims immune response. Nat Med 4, 1124–1125 (1998). https://doi.org/10.1038/2619
Issue Date:
DOI: https://doi.org/10.1038/2619
This article is cited by
-
Season and sex have different effects on hematology and cytokines in striped hamsters (Cricetulus barabensis)
Journal of Comparative Physiology B (2020)
-
Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica
Mucosal Immunology (2011)
-
Serum leptin in rheumatoid arthritis
Rheumatology International (2007)