Abstract
MANY nitrosamines are carcinogenic to a wide range of animal species1–4. The synthesis of nitrosamines from nitrite and secondary amines has been demonstrated in vitro with animal and human gastric juice5,6 and in vivo in animals6; nitrosamine synthesis was pH-dependent6–9. The synthesis of the non-carcinogenic diphenylnitrosamine has been reported in the human stomach after oral administration of nitrate and diphenylamine7. Nitrosamines can also be synthesized from nitrate and secondary amines in vitro at near neutral pH in the presence of enteric enteria10. We have demonstrated in vivo synthesis of nitrosopiperidine from nitrite and piperidine in the stomach and small intestine of the rat11. We report here in vivo synthesis of the carcinogenic nitrosopiperidine from nitrate and piperidine in the rat stomach and small intestine, and also with rat gastric contents in vitro.
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ALAM, B., SAPOROSCHETZ, I. & EPSTEIN, S. Synthesis of Nitrosopiperidine from Nitrate and Piperidine in the Gastro-intestinal Tract of the Rat. Nature 232, 199–200 (1971). https://doi.org/10.1038/232199a0
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DOI: https://doi.org/10.1038/232199a0
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