Abstract
USE of viral RNA or DNA information in the control of genetic deficiency and certain other diseases, including cancer, has been suggested by transduction with bacteriophage1 and by the recent report of the reduction in levels of blood arginine in certain animals and man as a result of infection with the Shope papilloma virus, which induces a virus-specific arginase2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Morse, M. L., Lederberg, E. M., and Lederberg, J., Genetics, 41, 758 (1956).
Rogers, S., Nature, 212, 1120 (1966).
Fraenkel-Conrat, H., in Proceedings in Nucleic Acid Research (edit. by Cantoni, G. C., and Davies, D. R.), 480 (Harper and Row, New York and London, 1966).
Singer, M. F., in Proceedings in Nucleic Acid Research (edit. by Cantoni, G. C., and Davies, D. R.), 245 (Harper and Row, New York and London, 1966).
Kaziro, Y., Grossman, A., and Ochoa, S., Proc. US Nat. Acad. Sci., 50, 54 (1963).
Stewart, J. W., and Stahman, M. A., in Poly Amino Acids, Poly Peptides and Proteins (edit. by Stahman, M. A.), 95 (University of Wisconsin Press, Madison, Wisconsin, 1962).
Pace, N. R., and Spiegelman, S., Science, 153, 64 (1966).
Goulian, M., Kornberg, A., and Sinsheimer, R. L., Proc. US Nat. Acad. Sci., 58, 2321 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROGERS, S., PFUDERER, P. Use of Viruses as Carriers of Added Genetic Information. Nature 219, 749–751 (1968). https://doi.org/10.1038/219749a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/219749a0
This article is cited by
-
Challenges, approaches and enablers: effectively triangulating towards dose selection in pediatric rare diseases
Journal of Pharmacokinetics and Pharmacodynamics (2023)
-
Gene therapy and gene correction: targets, progress, and challenges for treating human diseases
Gene Therapy (2022)
-
Long‐term safety and efficacy of AAV gene therapy in the canine model of glycogen storage disease type Ia
Journal of Inherited Metabolic Disease (2018)
-
History of Oncolytic Viruses: Genesis to Genetic Engineering
Molecular Therapy (2007)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.