Abstract
LEUKÆMIC cells of the mouse develop resistance to various analogues of folic acid1,2. The variant cells in certain cases depend upon the 4-amino-substituted folic antagonists for optimal growth3. The changes are found to be stable, irreversible and heritable4, and occur generally among many transplantable leukæmias5.
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LAW, L. Origin of the Resistance of Leukæmic Cells to Folic Acid Antagonists. Nature 169, 628–629 (1952). https://doi.org/10.1038/169628a0
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DOI: https://doi.org/10.1038/169628a0
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