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Perinatal Outcome of Pregnancies After Assisted Reproduction: A Case–Control Study

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Abstract

Purpose: A matched case–control study of all pregnancies obtained after either IVF or ICSI was conducted to investigate the perinatal outcome.

Methods: Three hundred eleven singleton and 115 twin pregnancies obtained after assisted reproduction were studied. Controls were selected from a regional register and were matched for maternal age, parity, singleton or twin pregnancy, and date of delivery.

Results: No significant difference was observed for gestational age at delivery, birth weight, incidence of congenital anomalies, and incidence of perinatal mortality between ART (singleton and twin) pregnancies and spontaneous controls. ART twin pregnancies showed a higher incidence of preterm deliveries than control pregnancies (52 vs 42%; P < 0.05) and needed more neonatal intensive care (47 vs 26%; P < 0.05).

Conclusions: From this case–control study it is concluded that the perinatal outcome of ART singleton pregnancies is not different from that in matched controls. ART twin pregnancies showed a higher incidence of preterm deliveries than control pregnancies and needed more neonatal intensive care.

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REFERENCES

  1. Lancaster PAL, Australian In Vitro Fertilization Collaborative Group: High incidence of preterm births and early losses in pregnancy after IVF. BMJ 1985;291:1160–1163

    Google Scholar 

  2. Beral V, Doyle P, MRC Working Party on Children Conceived by In Vitro Fertilisation: Births in Great Britain resulting from assisted conception, 1978–87. BMJ 1990;300:1229–1233

    Google Scholar 

  3. Seoud MA, Toner JP, Kruithoff C, Muasher SJ: Outcome of twin, triplet, and quadruplet in vitro fertilization pregnancies: The Norfolk experience. Fertil Steril 1992;57:825–834

    Google Scholar 

  4. Doyle P, Beral V, Macononchie N: Preterm delivery, low birth weight and small-for-gestational-age in liveborn singleton babies resulting from in-vitro fertilization. Hum Reprod 1992;7:425–428

    Google Scholar 

  5. Tan SL, Doyle P, Campbell S, et al.: Obstetric outcome of in vitro fertilization pregnancies compared with normally conceived pregnancies. Am J Obstet Gynecol 1992;167:778–784

    Google Scholar 

  6. Olivennes F, Rufat P, André B, Pourade A, Quiros MC, Frydman R: The increased risk of complication observed in singleton pregnancies resulting from in-vitro fertilization (IVF) does not seem to be related to the IVF method itself. Hum Reprod 1993;8:1297–1300

    Google Scholar 

  7. Rufat P, Olivennes F, de Mouzon J, Dehan M, Frydman R: Task force report on the outcome of pregnancies and children conceived by in vitro fertilization, France 1987–1989. Fertil Steril 1994;61:324–33

    Google Scholar 

  8. Wang JX, Clark AM, Kirby CA, et al: The obstetric outcome of singleton pregnancies following in vitro fertilization/gamete intra-fallopian transfer. Hum Reprod 1994;9:141–146

    Google Scholar 

  9. Kessler L, Lancet M, Borenstein R, Steinmetz A: The problem of the older primipara. Obstet Gynecol 1980;56:165–169

    Google Scholar 

  10. Ghazi HA, Spielberger C, Kallen B: Delivery outcome after infertility—a registry study. Fertil Steril 1991;55:726–732

    Google Scholar 

  11. Williams MA, Goldman MB, Mittendorf R, Monson RR: Subfertility and the risk of low birth weight. Fertil Steril 1991;56:668–671

    Google Scholar 

  12. Tuck SM, Yudkin PL, Turnbull AC: Pregnancy outcome in elderly primigravidae with an without a history of infertility. Br J Obstet Gynaecol 1988;95:230–237

    Google Scholar 

  13. Li TC, Macleod I, Singhal V, Duncan SLB: The obstetric and neonatal outcome of pregnancy in women with a previous history of infertility: A prospective study. Br J Obstet Gynaecol 1991;98:1087–1092

    Google Scholar 

  14. Petersen K, Hornnes PJ, Ellingsen S, Jensen F, Brocks V, Starup J, Ramsøe Jacobsen J, Nyboe Andersen A: Perinatal outcome after in vitro fertilization. Acta Obstet Gynecol Scand 1995;74:129–131

    Google Scholar 

  15. Bonduelle M, Legein J, Buysse A, Van Assche E, Wisanto A, Devroey P, Van Steirteghem A, Liebaers I: Prospective follow-up study of 423 children born after intracytoplasmic sperm injection. Hum Reprod 1996;11:1558–1564

    Google Scholar 

  16. Bonduelle M, Wilikens A, Buysse A, Devroey P, Van Steirteghem A, Liebaers I: Een follow-up-studie van kinderen geboren na intracytoplasmatische sperma-injectie. Tijdschrift Fertiliteitsonderzoek 1997;11:13–19

    Google Scholar 

  17. In 't Veld P, Brandenburg H, Verhoeff A, Dhont M, Los F: Sex chromosomal abnormalities and intracytoplasmic sperm injection. Lancet 1995;346:773

    Google Scholar 

  18. Van Opstal D, Los FJ, Ramlakhan S, Van Hemel JO, Van Den Ouweland AMW, Brandenburg H, Pieters MHEC, Verhoeff A, Vermeer MCS, Dhont M, In 't Veld PA: Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection. Hum Reprod 1997;12:682–686

    Google Scholar 

  19. Bonduelle M, Legein J, Derde MP, Buysse A, Schietecatte J, Wisanto A, Devroey P, Van Steirteghem A, Liebaers I: Comparative follow-up study of 130 children born after intracytoplasmic sperm injection and 130 children born after in-vitro fertilization. Hum Reprod 1995;10:3327–3331

    Google Scholar 

  20. De Neubourg F, Van Mullem A, Van der Elst J, Defoort P, De Sutter P, Dhont M: Comparative study of the perinatal outcome of 325 children born after in-vitro fertilization and 429 children born after intracytoplasmic sperm injection. 13th Annual Meeting of the European Society of Human Reproduction and Embryology. Edinburgh, United Kingdom, 22–25 June 1997. Hum Reprod 12, Abstract Book 1, Abstract 0–125

  21. Verlaenen H, Cammu H, Derde MP, Amy JJ: Singleton pregnancy after in-vitro fertilization: Expectations and outcome. Obstet Gynecol 1995;86:906–910

    Google Scholar 

  22. Tallo CP, Vohr B, Oh W, Rubin LP, Seifer DB, Haning RV Jr: Maternal and neonatal morbidity associated with in vitro fertilization. J Pediatr 1995;127:794–800

    Google Scholar 

  23. Tanbo T, Dale PO, Lunde O, Moe N, Abyholm T: Obstetric outcome in singleton pregnancies after assisted reproduction. Obstet Gynecol 1995;86:188–192

    Google Scholar 

  24. Bernasko J, Lynch L, Lapinski R, Berkowitz RL: Twin pregnancies conceived by assisted reproductive techniques: Maternal and neonatal outcomes. Obstet Gynecol 1997;89:368–372

    Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University Hospital, Ghent, De Pintelaan 185, UZ-Ghent, B-9000, Ghent, Belgium

    M. Dhont, F. De Neubourg, J. Van der Elst & P. De Sutter

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  1. M. Dhont
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  2. F. De Neubourg
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  3. J. Van der Elst
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  4. P. De Sutter
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Dhont, M., De Neubourg, F., Van der Elst, J. et al. Perinatal Outcome of Pregnancies After Assisted Reproduction: A Case–Control Study. J Assist Reprod Genet 14, 575–580 (1997). https://doi.org/10.1023/A:1022576500894

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  • DOI: https://doi.org/10.1023/A:1022576500894

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