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Neuritic Alterations and Neural System Dysfunction in Alzheimer's Disease and Dementia with Lewy Bodies

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Abstract

Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders that share progressive dementia as the common major clinical symptom. Damages to memory-related brain structures are the likely pathological correlate, and in both illnesses deposition of amyloidogenic proteins are present mainly within these limbic structures. Amyloid-β–positive plaques and phospho-tau–positive neurofibrillary tangles are the main feature of AD and α-synuclein–positive Lewy bodies and Lewy neurites are found in DLB. Interestingly the associated proteins also interfere with synaptic function and synaptic plasticity. Here, we propose that the same neuronal circuits are disturbed within the hippocampal formation in AD and DLB and that in both diseases the associated proteins might lead to changes in synaptic plasticity and function. Thus both classic neuropathological changes and cellular dysfunctions might contribute to the cognitive impairments in AD and DLB.

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Authors and Affiliations

  1. Alzheimer's Disease Research Laboratory, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts

    J. Klucken, P. J. McLean, M. Ingelsson & Bradley T. Hyman

  2. Servicio de Neurologia, Fundacion Jimenez Diaz, 28040, Madrid, Spain

    E. Gomez-Tortosa

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  1. J. Klucken
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  2. P. J. McLean
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  3. E. Gomez-Tortosa
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  4. M. Ingelsson
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  5. Bradley T. Hyman
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Correspondence to Bradley T. Hyman.

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Klucken, J., McLean, P.J., Gomez-Tortosa, E. et al. Neuritic Alterations and Neural System Dysfunction in Alzheimer's Disease and Dementia with Lewy Bodies. Neurochem Res 28, 1683–1691 (2003). https://doi.org/10.1023/A:1026061021946

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