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Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats

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Abstract

Extracts of Phellinus linteus (EPB), grown on germinated brown rice, protected rats from liver injury induced by carbon tetrachloride (CCl4). Peroxidation products in the liver were decreased to 10% by EPB. Catalase and superoxide dismutase activities were significantly decreased to 55% and 39% by CCl4 administration, but EPB blocked this effect, resulting in enzyme activities at control levels. Expression of cytochrome P450 2E1 (CYP2E1) protein was significantly decreased to 88% in CCl4-treated rats but remained at control levels when EPB was also administered. EPB did not affect the altered fatty acid composition induced by CCl4. The hepatoprotective effect of EPB may be mediated by EPB's prevention of CCl4-induced CYP2E1 degradation.

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Authors and Affiliations

  1. Department of Applied Biology and Chemistry, Konkuk University, Seoul, 143-701, Republic of Korea

    Tae Il Jeon, Beong Ou Lim & Dong Ki Park

  2. Department of Dairy Science, Hankyong National University, Ansung, 456-749, Republic of Korea

    Seong-Gu Hwang

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  1. Tae Il Jeon
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  2. Seong-Gu Hwang
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  3. Beong Ou Lim
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  4. Dong Ki Park
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Correspondence to Dong Ki Park.

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Jeon, T.I., Hwang, SG., Lim, B.O. et al. Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats. Biotechnology Letters 25, 2093–2096 (2003). https://doi.org/10.1023/B:BILE.0000007071.28105.c1

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  • DOI: https://doi.org/10.1023/B:BILE.0000007071.28105.c1

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