Skip to main content
SpringerLink
Log in

Stability of L-[S-methyl-11C]methionine solutions

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

For clinical PET studies L-[S-methyl-11C]methionine ([11C]MET) solutions have been prepared in both high doses and specific activities (up to 48.1 GBq and 370 GBq/mmol, respectively) with high radiochemical purity (>99%). The stability of these preparations was investigated by HPLC to ensure the radiopharmaceutical efficacy during the usable shelf life. Under our routine conditions the observed radiochemical purity loss never exceeded 3.5% one hour after EOS. The decomposition rate was affected by total activity and chemical composition of the solutions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. R. R. Mac Gregor,D. J. Schlyer,J. Fowler,A. P. Wolf,C. Y. Shiue, J. Nucl. Med., 28 (1987) 60.

    Google Scholar 

  2. K. Suzuki,O. Inoue,K. Tamate,F. Mikado, Appl. Radiation Isotopes, 41 (1990) 593.

    Google Scholar 

  3. C. Pascali,A. Bogni,R. Iwata,D. Decise,F. Crippa,E. Bombardieri, J. Labeled Comp. Radiopharm., 42 (1999) 715.

    Google Scholar 

  4. T. Kato,K. Saito,N. Kurihara, Appl. Radiation Isotopes, 45 (1994) 693.

    Google Scholar 

  5. E. A. Evans, Review 16 - Amersham Corporation, 1982.

  6. G. J. Mayer,H. H. Coenen,S. L. Waters,B. Langstrom,R. Cantineau,K. Strijckmans,W. Vaalburg,C. Halldin,C. Crouzel,B. Maziere,A. Luxen, in: Radiopharmaceuticals for Positron Emission Tomography. Methodological Aspects, Kluwer Academic Publishers, The Netherlands, 1993, p. 91.

    Google Scholar 

  7. European Pharmacopoeia Commission. General Monograph of Radiopharmaceutic Preparation, PA/PH/Exp 14/T (97) 6, ANP.

  8. M. Anbar,P. Neta, Appl. Radiation Isotopes, 18 (1967) 493.

    Google Scholar 

  9. N. Getoff,S. Solar,G. Lubec, Life Sci., 63 (1998) 1469.

    Google Scholar 

  10. K. Nagren, in: PET Studies on Amino Acid Metabolism and Protein Synthesis, Kluwer Academic Publishers, The Netherlands, 1993, p. 81.

    Google Scholar 

  11. P. E. Correa,D. P. Riley, J. Org. Chem., 50 (1985) 1787.

    Google Scholar 

  12. P. W. D. Scislowski,E. J. Davis, FEBS Lett., 224 (1987) 177.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, National Cancer Institute, V. Venezian, 1, 20133, Milan, Italy

    A. Bogni, E. Bombardieri, L. Cadini & C. Pascali

  2. Graduate School of Engineering, Tohoku University, Aramaki, Aoba-ku, Sendai, 980-8578, Japan

    R. Iwata

Authors
  1. A. Bogni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Bombardieri
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Iwata
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. Cadini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Pascali
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bogni, A., Bombardieri, E., Iwata, R. et al. Stability of L-[S-methyl-11C]methionine solutions. Journal of Radioanalytical and Nuclear Chemistry 256, 199–203 (2003). https://doi.org/10.1023/A:1023964712999

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1023964712999

Keywords

Search

Navigation