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In Vivo NMR Studies of Neurodegenerative Diseases in Transgenic and Rodent Models

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Abstract

In vivo magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) provide unique quality to attain neurochemical, physiological, anatomical, and functional information noninvasively. These techniques have been increasingly applied to biomedical research and clinical usage in diagnosis and prognosis of diseases. The ability of MRS to detect early yet subtle changes of neurochemicals in vivo permits the use of this technology for the study of cerebral metabolism in physiological and pathological conditions. Recent advances in MR technology have further extended its use to assess the etiology and progression of neurodegeneration. This review focuses on the current technical advances and the applications of MRS and MRI in the study of neurodegenerative disease animal models including amyotrophic lateral sclerosis, Alzheimer's, Huntington's, and Parkinson's diseases. Enhanced MR measurable neurochemical parameters in vivo are described in regard to their importance in neurodegenerative disorders and their investigation into the metabolic alterations accompanying the pathogenesis of neurodegeneration.

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Authors and Affiliations

  1. The Nathan S. Kline Institute, Center for Advanced Brain Imaging, Orangeburg, New York, 10962

    In-Young Choi, Sang-Pil Lee, David N. Guilfoyle & Joseph A. Helpern

  2. Departments of Radiology, Psychiatry and Physiology & Neuroscience, New York University School of Medicine, New York, New York, 10016

    Joseph A. Helpern

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Choi, IY., Lee, SP., Guilfoyle, D.N. et al. In Vivo NMR Studies of Neurodegenerative Diseases in Transgenic and Rodent Models. Neurochem Res 28, 987–1001 (2003). https://doi.org/10.1023/A:1023370104289

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