Abstract
Functional and behavioral disturbances associated with hydrocephalus may be due in part to altered neurotransmitter function in the brain. Hydrocephalus was induced in adult rabbits by injection of silicone oil into the cisterna magna. These and controls were killed 3 days, 1 and 4 weeks post-injection. Tissue concentrations of norepinephrine, epinephrine, serotonin, dopamine, and the metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3,4-dihydroxyphenylacetic acid (DOPAC) levels were determined in fifteen brain regions using HPLC. There were decreases in hypothalamic and medullary dopamine, transient decreases in basal ganglia serotonin, increases in thalamic noradrenaline, and increases in hypothalamic and thalamic epinephrine. Changes in the primary neurotransmitters may be attributable to damage of their axonal projection systems. Metabolite concentrations increased in the cerebrum. Reduced clearance of extracellular fluid which accompanies cerebrospinal fluid stasis may explain the accumulation of metabolites.
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REFERENCES
Mori, K., Shimada, J., Kurisaka, M., Sato, K., and Watanabe, K. 1995. Classification of hydrocephalus and outcome of treatment. Brain Dev. 17:338-348.
Katzman, R. 1977. Normal pressure hydrocephalus. Contemp. Neurol. Ser. 15:69-92.
Laurence, K. M., and Coates, S. 1962. Further thoughts on the natural history of hydrocephalus. Dev. Med. Child Neurol. 4:263-267.
Del Bigio, M. R. 1993. Neuropathological changes caused by hydrocephalus. Acta Neuropathol. 85:573-585.
Hartmann, J., Kunig, G., and Riederer, P. 1993. Involvement of transmitter systems in neuropsychiatric diseases. Acta Neurol. Scand. (Suppl.) 146:18-21.
Del Bigio, M. R. 1989. Hydrocephalus-induced changes in the composition of cerebrospinal fluid. Neurosurgery 25:416-423.
Iacono, R. P., Sandyk, R., Borovich, B., and Labadie, E. 1987. The opioid system and the reversibility of the dementia in normal pressure hydrocephalus. Intern. J. Neurosci. 36:119-121.
Inagawa, T., Ishikawa, S., and Uozumi, T. 1980. Homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular CSF of comatose patients with obstructive hydrocephalus. J. Neurosurg. 52:635-641.
Chovanes, G. I., McAllister, J. P., Lamperti, A. A., Salotto, A. G., and Truex, R. C. 1988. Monoamine alterations during experimental hydrocephalus in neonatal rats. Neurosurgery 22:86-91.
Ehara, K., Matsumoto, S., Yoshida, N., Kuno, T., and Tanaka, C. 1982. Ascending norepinephrine pathways impaired in experimental hydrocephalus. Jap. J. Pharmacol. 32:205-208.
Ehara, K., Tanaka, C., Tamaki, N., and Matsumoto, S. 1991. Changes in the hypothalamic and brain stem catecholaminergic systems in experimental hydrocephalus: a histochemical observation. 75-87 75–87, in Matsumoto, S., and Tamaki, N. (eds.), Hydrocephalus: Pathogenesis and Treatment, Springer-Verlag, Tokyo.
Higashi, K., Asahisa, H., Ueda, N., Kobayashi, K., Hara, K., and Noda, Y. 1986. Cerebral blood flow and metabolism in experimental hydrocephalus. Neurol. Res. 8:169-176.
Miyake, H., Eghwrudjakpor, P., Sakamoto, T., Kurisaka, M., and Mori, K. 1991. Neurotransmitter changes in hydrocephalus: effects of cerebral metabolic activator on kaolin-induced hydrocephalus. 68-74 68–74, in Matsumoto, S., and Tamaki, N. (eds.). Hydrocephalus: Pathogenesis and Treatment, Springer-Verlag, Tokyo.
Miyake, H., Eghwrudjakpor, P. O., Sakamoto, T., and Mori, K. 1992. Catecholamine alterations in experimental hydrocephalus. Child's Nerv. Syst. 8:243-246.
Lovely, T. J., McAllister, J. P., Miller, D. W., Lamperti, A. A., and Wolfson, B. J. 1989. Effects of hydrocephalus and surgical decompression on cortical norepinephrine levels in neonatal cats. Neurosurgery 24:43-52.
Edvinsson, L., Nielsen, K. C., Owman, C., Rosengren, E., and West, K. A. 1972. Concomitant fall in brain dopamine and homovanillic acid in hydrocephalic rabbits. Exp. Neurol. 37:647-649.
Miwa, S., Inagaki, C., Fujiwara, M., and Takaori, S. 1982. The activities of noradrenergic and dopaminergic neuron systems in experimental hydrocephalus. J. Neurosurg. 57:67-73.
Owman, C., Rosengren, E., and West, K. A. 1971. Influence of various intracranial pressure levels on the concentration of certain arylethylamines in rabbit brain. Experientia 27:1036-1037.
Gispen, W. H., Schotman, P., and De Kloet, E. R. 1972. Brain RNA and hypophysectomy: A topographical study. Neuroendocrinology 9:285-296.
Del Bigio, M. R., and Bruni, J. E. 1987. Cerebral water content in silicone oil-induced hydrocephalic rabbits. Pediatr. Neurosci. 13:72-77.
Gerlo, E., and Malfait, R. 1985. High-performance liquid chromatographic assay of free norepinephrine, epinephrine, dopamine, vanillymandelic acid and homovanillic acid. J. Chromatogr. 343:9-20.
Del Bigio, M. R., and Bruni, J. E. 1988. Periventricular pathology in hydrocephalic rabbits before and after shunting. Acta Neuropathol. 77:186-195.
Reader, T. A., Dewar, K. M., and Grondin, L. 1989. Distribution of monoamines and metabolities in rabbit neostriatum, hippocampus and cortex. Brain Res. Bull. 23:237-247.
Dewar, K. M., Reader, T. A., Grondin, L., and Descarries, L. 1991. [3H]paroxetine binding and serotonin content of rat and rabbit cortical areas, hippocampus, neostriatum, ventral mesencephalic tegmentum, and midbrain raphe nuclei region. Synapse 9:14-26.
Levitt, P., Rakic, P., and Goldman-Rakic, P. S. 1984. Comparative assessment of monoamine afferents in mammalian cerebral cortex. 41-59 41–59, in Descarries, L., Reader, T. R., and Jasper, H. H. (eds.), Monoamine Innervation of the Cerebral Cortex, Alan R. Liss, Inc., New York.
Nieuwenhuys, R. 1985. Chemoarchitecture of the Brain., Springer-Verlag, Berlin 246.
Del Bigio, M. R., and Bruni, J. E. 1987. Chronic intracranial pressure monitoring in conscious hydrocephalic rabbits. Pediatr. Neurosci. 13:67-71.
Del Bigio, M. R., and Bruni, J. E. 1991. Silicone oil-induced hydrocephalus in the rabbit. Child's Nerv. Syst. 7:79-84.
Del Bigio, M. R., Cardoso, E. R., and Halliday, W. C. 1997. Neuropathological changes in chronic adult hydrocephalus: cortical biopsies and autopsy findings. Can. J. Neurol. Sci. 24:121-126.
Kawano, T., Tsujimura, M., Mori, K., and Eujita, Y. 1980. [Changes in ventricular dopamine and homovanillic acid concentrations in hydrocephalic patients.] (translated from Japanese). Neurol. Med. Chir. (Tokyo) 20:373-378.
Curran, T., and Lang, A. E. 1994. Parkinsonian syndromes associated with hydrocephalus: case reports, a review of the literature, and pathophysiological hypothesis. Movement Disorders 9:508-520.
Suzuki, F., Handa, J., and Maeda, T. 1992. Effects of congenital hydrocephalus on serotonergic input and barrel cytoarchitecture in the developing somatosensory cortex of rats. Child's Nerv. Syst. 8:18-24.
Andersson, H., and Roos, B. E. 1969. 5-Hydroxyindoleacetic acid in cerebrospinal fluid of hydrocephalic children. Acta Paediatr. Scand. 58:601-608.
Malm, J., Kristensen, B., Ekstedt, J., and Wester, P. 1994. CSF concentration gradients of monoamine metabolites in patients with hydrocephalus. J. Neurol. Neurosurg. Psychiatr. 57:1026-1033.
Olmstead, C. E., Lazareff, J. A., Orlino, E. N., Fluharty, A. L., Faull, K. F., Peacock, W. J., Wehby-Grant, M. C., Gayek, R. J., and Fisher, R. S. 1995. Neuroamine related compounds in the CSF of hydrocephalic rabbits. Neuroreport 6:1769-1772.
Mefford, I. N. 1988. Epinephrine in mammalian brain. Prog. Neuro-psychopharmacol. Biol. Psychiatr. 12:365-388.
Roth, K. A., Mefford, I. M., and Barchas, J. D. 1982. Epinephrine, norepinephrine, dopamine and serotonin: differential effects of acute and chronic stress on regional brain amines. Brain Res. 239:417-424.
Bach-y-Rita, P. 1993. Neurotransmission in the brain by diffusion through the extracellular fluid: a review. NeuroReport 4:343-350.
Cohen, Z., Bonvento, G., Lavcombe, P., and Hamel, E. 1996. Serotonin in the regulation of brain microcirculation. Prog. Neurobiol. 50:335-362.
Larsson, A., Bergh, A. C., Bilting, M., Arlig, A., Jacobsson, L., Stephensen, H., and Wikkelso, C. 1994. Regional cerebral blood flow in normal pressure hydrocephalus diagnostic and prognostic aspects. Eur. J. Nuclear Med. 21:118-123.
Lindqvist, G., Andersson, H., Biliting, M., Blomstrand, C., Malmgren, H., and Wikkelso, C. 1993. Normal pressure hydrocephalus: psychiatric findings before and after shunt operation classified in a new diagnostic system for organic psychiatry. Acta Psychiatr. Scand. 88 Suppl. 373:18-32.
McLone, D. G., Bondareff, W., and Raimondi, A. J. 1971. Brain edema in the hydrocephalic hy-3 mouse: submicroscopic morphology. J. Neuropathol. Exp. Neurol. 30:627-637.
Nicholson, C. 1989. Issues involved in the transmission of chemical signals through the brain extracellular space. Acta Morphol. Neerl. Scand. 26:69-80.
Girgis, M., and Wang, S.-C. 1981. A New Stereotaxic Atlas of the Rabbit Brain., Warren H. Green, Inc., St. Louis, MO 70.
Rose, M. 1931. Cytoarchitektonischer Atlas der Grosshirnrinde des Kaninchens. J. Psycholog. Neurolog. 43:353-440.
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Del Bigio, M.R., Bruni, J.E. & Vriend, J.P. Monoamine Neurotransmitters and Their Metabolites in the Mature Rabbit Brain Following Induction of Hydrocephalus. Neurochem Res 23, 1379–1386 (1998). https://doi.org/10.1023/A:1020798622692
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DOI: https://doi.org/10.1023/A:1020798622692