Abstract
The carbohydrate determinants, sialyl Lewis A and sialyl Lewis X, which are frequently expressed on human cancer cells, serve as ligands for a cell adhesion molecule of the selectin family, E-selectin, which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer. The initial adhesion mediated by these molecules triggers activation of integrin molecules through the action of several cytokines and leads to the extravasation of cancer cells. Cancer cells also produce humoral factors that facilitate E-selectin expression on endothelial cells. The degree of expression of the carbohydrate ligands at the surface of cancer cells is well correlated with the frequency of hematogenous metastasis and prognostic outcome of patients with cancers. The alteration of glycosyltransferase activities that leads to the enhanced expression of these carbohydrate ligands on cancer cell surface are currently being investigated.
Similar content being viewed by others
References
Takada A, Ohmori K, Takahashi N, Tsuyuoka K, Yago K, Zenita K, Hasegawa A, Kannagi R (1991) Biochem Biophys Res Commun 179: 713–19.
Takada A, Ohmori K, Yoneda T, Tsuyuoka K, Hasegawa A, Kiso M, Kannagi R (1993) Cancer Res 53: 354–61.
Majuri M-L, Mattila P, Renkonen R (1992) Biochem Biophys Res Commun 182: 1376–82.
Merwin JR, Madri JA, Lynch M (1992) Biochem Biophys Res Commun 189: 315–23.
Zaifert K, Cohen MC (1993) Clin Immunol Immunopathol 68: 51–56.
Lowe JB, Stoolman LM, Nair RP, Larsen RD, Berhend TL, Marks RM (1990) Cell 63: 475–84.
Phillips ML, Nudelman E, Gaeta FCA, Perez M, Singhal AK, Hakomori S, Paulson JC (1990) Science 250: 1130–32.
Walz G, Aruffo A, Kolanus W, Bevilacqua M, Seed B (1990) Science 250: 1132–35.
Tyrrell D, James P, Rao N, Foxall C, Abbas S, Dasgupta F, Nashed M, Hasegawa A, Kiso M, Asa D, Kidd J, Brandley BK (1991) Proc Natl Acad Sci USA 88: 10372–76.
Berg EL, Robinson MK, Mansson O, Butcher EC, Magnani JL (1991) J Biol Chem 266: 14869–72.
Dejana E, Martin Padura I, Lauri D, Bernasconi S, Bani MR, Garofalo A, Giavazzi R, Magnani J, Mantovani A, Menard S (1992) Lab Invest 66: 324–30.
Kannagi R, Kitahara A, Itai S, Zenita K, Shigeta K, Tachikawa T, Noda A, Hirano H, Abe M, Shin S, Fukushi Y, Hakomori S, Imura H (1988) Cancer Res 48: 3856–63.
Itai S, Nishikata J, Yoneda T, Ohmori K, Tsunekawa S, Hiraiwa N, Yamabe H, Arii S, Tobe T, Kannagi R (1991) Cancer 67: 1576–87.
Miyake M, Zenita K, Tanaka O, Okada Y, Kannagi R (1988) Cancer Res 48: 715–58.
Zenita K, Kirihata Y, Kitahara A, Shigeta K, Higuchi K, Hirashima K, Murachi T, Miyaka M, Takeda T, Kannagi R (1988) Int J Cancer 41: 344–49.
Kannagi R, Fukushi Y, Tachikawa T, Noda A, Shin S, Shigeta K, Hiraiwa N, Fukuda Y, Inamoto T, Hakomori S, Imura H (1986) Cancer Res 46: 2619–26.
Iwai K, Ishikura H, K aji M, Sugiura H, Ishizu A, Takahashi C, Kato H, Tanabe T, Yoshiki T (1993) Int J Cancer 54: 972–77.
Ohmori K, Takada A, Ohwaki I, Takahashi N, Furukawa Y, Maeda M, Kiso M, Hasegawa A, Kannagi M, Kannagi R (1993) Blood 82(9): 2797–805.
Furukawa Y, Tara M, Ohmori K, Kannagi R (1994) Cancer Res 54: 6533–38.
Kannagi R, Magnani JL (1995) in Leukocyte Typing V (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder TF, Todd RF, eds) pp 1529–1531. Oxford: Oxford University Press.
Matsushita Y, Cleary KR, Ota DM, Hoff SD, Irimura T (1990) Lab Invest 63: 780–91.
Shirahama T, Ikoma M, Muramastu T, Ohi Y (1992) J Urol 148: 1319–22.
Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Kabuto T, Iwanaga T, Matsushita Y, Irimura T (1993) Cancer Res 53: 3632–37.
Kiriyama K, Watanabe T, Sakamoto J, Ito K, Akiyama S, Yamauchi M, Takagi H (1991) Nippon Geka Gakkai Zasshi 92: 320–30 (in Japanese).
Kiriyama K, Watanabe T (1994) in Complex Carbohydrates (Kannagi R, ed.) pp 67–76. Tokyo: Medical View Inc. (in Japanese).
Shimono R, Mori M, Akazawa K, Adachi Y, Sugimachi K (1994) Am J Gastroenterol 89: 101–5.
Nakayama T, Watanabe M, Katsumata T, Teramoto T, Kitajima M (1995) Cancer 75: 2051–56.
Narita T, Funahashi H, Satoh Y, Watanabe T, Sakamoto J, Takagi H (1993) Cancer 71: 3044–53.
Ye C, Kiriyama K, Mitsuoka C, Kannagi R, Ito K, Watanabe T, Kondo K, Akiyama S, Takagi H (1995) Int J Cancer 61: 455–60.
Narita T, Kawakami-Kimura N, Kasai Y, Hosono J, Nakashio T, Matsuura N, Sato M, Kannagi R (1996) J Gastroenterol 31: 299–301.
Kawakami-Kimura N, Narita T, Ohmori K, Yoneda T, Matsumoto K, Nakamura T, Kannagi R (1996) Br J Cancer 75: 47–53.
Sato M, Narita T, Kawakami-Kimura N, Higashiyama S, Taniguchi N, Akiyama S, Hashimoto T, Manabe T, Kannagi R (1996) Cancer Lett 102: 183–191.
Narita T, Kawakami-Kimura N, Sato M, Matsuura N, Higashiyama S, Taniguchi N, Kannagi R (1996) Oncology (in press).
Aruffo A, Dietsch MT, Wan H, Hellstrom KE, Hellstrom I (1992) Proc Natl Acad Sci USA 89: 2292–96.
Hakomori S (1994) Biochem Biophys Res Commun 203: 1605–13.
Mannori G, Crottet P, Cecconi O, Hanasaki K, Aruffo A, Nelson RM, Varki A, Bevilacqua MP (1995) Cancer Res 55: 4425–31.
Handa K, White T, Ito K, Fang H, Wang S-S, Hakomori S-I (1995) Int J Oncol 6: 773–81.
Moore KL, Eaton SF, Lyons DE, Lichenstein HS, Cummings RD, McEver RP (1994) J Biol Chem 269: 23318–27.
Asa D, Raycroft L, Ma L, Aeed PA, Kaytes PS, Elhammer AP, Geng J-G (1995) J Biol Chem 270: 11662–70.
Moore KL, Patel KD, Bruehl RE, Fugang L, Johnson DA, Lichenstein HS, Cummings RD, Bainton DF, McEver RP (1995) J Cell Biol 128: 661–71.
Ma L, Raycroft L, Asa D, Anderson DC, Geng J-G (1994) J Biol Chem 269: 27739–46.
Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (1990) Genes Devel 4, 1288–303.
Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi Rosso G, Lobb R (1990) Cell 63: 1349–56.
Lowe JB, Kukowska-Latallo JF, Nair RP, Larsen RD, Marks RM, Macher BA, Kelly RJ, Ernst LK (1991) J Biol Chem 266: 17467–77.
Koszdin KL, Bowen BR (1992) Biochem Biophys Res Commun 187: 152–57.
Weston BW, Nair RP, Larsen RD, Lowe JB (1992) J Biol Chem 267: 4152–60.
Weston BW, Smith PL, Kelly RJ, Lowe JB (1992) J Biol Chem 267: 24575–84.
Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T (1994) J Biol Chem 269: 14730–37.
Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (1994) J Biol Chem 269: 16789–94.
Yago K, Zenita K, Ginya H, Sawada M, Ohmori K, Okuma M, Kannagi R, Lowe JB (1993) Cancer Res 53: 5559–65.
Dall'Olio F, Chiricolo M, Lollini P, Lau JTY (1995) Biochem Biophys Res Commun 211: 554–61.
Majuri ML, Niemelaä R, Tiisala S, Renkonen O, Renkonen R (1995) Int J Cancer 63: 551–59.
Ho H, Hiraiwa N, Sawada-Kasugai M, Akamatsu S, Tachikawa T, Kasai Y, Akiyama S, Ho K, Takagi H, Kannagi R (1997) Int J Cancer (in press).
Dohi T, Hashiguchi M, Yamamoto S, Morita H, Oshima M (1994) Cancer 73: 1552–61.
Akamatsu S, Yazawa S, Tachikawa T, Furuta T, Nakamura J, Asao T, Nagamachi Y (1996) Cancer 77Suppl: 1694–1700.
Kemmner W, Krueck D, Schlag P (1994) Clin Exp Metastasis 12: 245–54.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kannagi, R. Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer. Glycoconj J 14, 577–584 (1997). https://doi.org/10.1023/A:1018532409041
Issue Date:
DOI: https://doi.org/10.1023/A:1018532409041