Abstract
Rotaviruses are the major cause of severe gastroenteritis in young children and animals. The rotavirus genome is composed of eleven segments of double-stranded RNA and can undergo genetic reassortment during mixed infections, leading to progeny viruses with novel or atypical phenotypes. There are numerous descriptions of rotavirus strains isolated from human and animals that share genetic and antigenic features of viruses from heterologous species. In many cases, genetic analysis by hybridization has clearly demonstrated the genetic relatedness of gene segments to those from viruses isolated from different species. Together with the observation that some virus strains appear to have been transmitted to a different species as a whole genome constellation, these data suggest that interspecies transmission occurs naturally, albeit at low frequencies. Although interspecies transmission has not been documented directly, there is an increasing number of reports of atypical rotaviruses that are apparently derived from transmission between: humans, cats and dogs; humans and cattle; humans and pigs; pigs and cattle; and pigs and horses. Interspecies evolutionary relationships are supported by phylogenetic analysis of rotavirus genes from different species. The emergence of novel strains derived from interspecies transmission has implications for the design and implementation of successful human rotavirus vaccine strategies.
Similar content being viewed by others
References
Kapikian A.Z., and Chanock R.M., Rotaviruses, in: Fields B.N., Knipe D.M., Howley P.M., Chanock R.M., Melnick J.L., Monath T.P., Roizman B., Strauss S.E. (eds), Fields Virology. 3rd edn, Lippincott-Raven Press, Philadelphia 1996, pp. 1657-1708.
Glass R.I., Gentsch J.R., and Ivanoff B., Science 272, 46-48, 1996.
Desselberger U., and Estes M.K., Future rotavirus research. in: Gray J., and Desselberger U. (eds), Methods in Molecular Medicine, vol. 34, Rotaviruses: methods and protocols. Humana Press Inc., Totowa, 2000, pp. 239-258.
Murphy T.V., Gargiullo P.M., Massoudi M.S., Nelson D.B., Jumaan A.O., Okoro C.A., Zanardi L.R., Setia S., Fair E., LeBaron C.W., Wharton M., and Livingood J.R., N Engl J Med 344, 564-572, 2001.
Nakagomi O., Nakagomi T., Oyamada H., Suto T., J Med Virol, 17, 29-34, 1985.
Desselberger U., Rotaviruses: basic facts, in: Gray J., and Desselberger U. (eds), Methods in Molecular Medicine, vol. 34, Rotaviruses: methods and protocols. Humana Press Inc., Totowa, 2000, pp. 1-8.
Ramig R.F., Ann Rev Microbiol 51, 225-255, 1997.
Estes M.K., Rotaviruses and their replication, in: Fields B.N., Knipe D.M., Howley P.M., Chanock R.M., Melnick J.L., Monath T.P., Roizman B., and Strauss S.E. (eds), Fields Virology. 3rd edn, Lippincott-Raven Press, Philadelphia, pp. 1625-1655, 1996.
Palombo E.A., FEMS Microbiol Lett 181, 1-8, 1999.
Desselberger U., Adv Virus Res 46, 69-95, 1996.
Webster R.G., Bean W.J., Gorman O.T., Chambers T.M., and Kawaoka Y., Microbiol Rev 56, 152-179, 1992.
Horimoto T., and Kawaoka Y., Clin Microbiol Rev 14, 129-149, 2001.
Iturriza-Gomara M., Isherwood B., Desselberger U., and Gray J., J Virol 75, 3696-3705, 2001.
Nakagomi O., and Nakagomi T., Microbiol Immunol 37, 337-348, 1993.
Gerna G., Sarasini A., Parea M., Arista S., Miranda P., Brussow H., Hoshino Y., and Flores J., J Clin Microbiol 30, 9-16, 1992.
Pongsuwanna Y., Taniguchi K., Chiwakul M., Urasawa T., Wakasugi F., Jayavasu C., and Urasawa S., J Clin Microbiol 34, 1050-1057, 1996.
Palombo E.A., Clark R., and Bishop R.F., J Med Virol 60, 56-62, 2000.
Nakagomi T., and Nakagomi O., J Virol 63, 1431-1434, 1989.
Nakagomi O., Nakagomi T., Arch Virol 120, 43-55, 1991.
Greenberg H., McAuliffe V., Valdesuso J., Wyatt R., Flores J., Kalica A., Hoshino Y., and Singh N., Infect Immun 39, 91-99, 1983.
Aboudy Y., Shif I., Zilberstein I., and Gotlieb-Stematsky T., J Med Virol 25, 351-359, 1988.
Nakagomi O., Mochizuki M., Aboudy Y., Shif I., Silberstein I., Nakagomi T., J Clin Microbiol 30, 1011-1013, 1992.
Birch C.J., Heath R.L., Marshall J.A., Liu S., Gust I.D., J Gen Virol 66, 2731-2735, 1985.
Iizuka M., Kaga E., Chiba M., Masamune O., Gerna G., and Nakagomi O., Arch Virol 135, 427-432, 1994.
Li B., Clark H.F., and Gouvea V., Virology 196, 825-830, 1993.
Gouvea V., Ramirez C., Li B., Santos N., Saif L., Clark H.F., and Hoshino Y., J Clin Microbiol 31, 917-923, 1993.
Li B., Clark H.F., and Gouvea V., J Gen Virol 75, 215-219, 1994.
Nakagomi T., and Nakagomi O., Arch Virol 145, 2403-2409, 2000.
Isegawa Y., Nakagomi O., Nakagomi T., and Ueda S., J Gen Virol 73, 1939-1946, 1992.
Nakagomi O., Kaga E., and Nakagomi T., Arch Virol 127, 365-371, 1992.
Gollop R., Nakagomi O., Silberstein I., Shulman L.M., Greenberg H.B., Mendelson E., and Shif I., Arch Virol 143, 263-277, 1998.
Snodgrass D.R., Fitzgerald T., Campbell I., Scott F.M., Browning G.F., Miller D.L., Herring A.J., and Greenberg H.B., J Clin Microbiol 28, 504-507, 1990.
Palombo E.A., and Bishop R.F., J Med Virol 47, 348-354, 1995.
Cooney M.A., Gorrell R.J., and Palombo E.A., J Med Microbiol 50, 462-467, 2001.
Gerna G., Sears J., Hoshino Y., Steele A.D., Nakagomi O., Sarasini A., and Flores J., Virology 200, 66-71, 1994.
Burke B., and Desselberger U., Virology 218, 299-305, 1996.
Arista S., Vizzi E., Alaimo C., Palermo D., and Cascio A., J Clin Microbiol 37, 2706-2708, 1999.
Mphahlele M.J., Peenze I., and Steele A.D., Arch Virol 144, 1027-1034, 1999.
Hasegawa A., Inouye S., Matsuno S., Yamaoka K., Eko R., and Suharyono W., Microbiol Immunol 28, 719-722, 1984.
Gerna G., Sarasini A., Zentilin L., Di Matteo A., Miranda P., Parea M., Battaglia M., and Milanesi G., Arch Virol 112, 27-40, 1990.
Browning G.F., Snodgrass D.R., Nakagomi O., Kaga E., Sarasini A., and Gerna G., Arch Virol 125, 121-128, 1992.
Nakagomi O., Isegawa Y., Ward R.L., Knowlton D.R., Kaga E., Nakagomi T., and Ueda S., Arch Virol 137, 381-388, 1994.
Brussow H., Gerna G., Sidoti J., and Sarasini A., J Clin Microbiol 30, 911-914, 1992.
Brussow H., and Sidoti J., Epidemiol Infect 106, 415-420, 1991.
Kelkar S.D., Ray P.G., Bedekar S.S., J Diarrhoeal Dis Res 14, 101-106, 1996.
Dunn S.J., Greenberg H.B., Ward R.L., Nakagomi O., Burns J.W., Vo P.T., Pax K.A., Das M., Gowda K., and Rao C.D., J Clin Microbiol 31, 165169, 1993.
Santos N., Lima R.C., Pereira C.F., and Gouvea V., J Clin Microbiol 36, 2727-2729, 1998.
Brussow H., Nakagomi O., Minamoto N., and Eichhorn W., J Gen Virol 73, 18731875, 1992.
Gouvea V., de Castro L., Timenetsky M.D., Greenberg H., and Santos N., J Clin Microbiol 32, 1408-1409, 1994.
Leite J.P., Alfieri A.A., Woods P.A., Glass R.I., and Gentsch J.R., Arch Virol 141, 2365-2374, 1996.
Racz M.L., Kroeff S.S., Munford V., Caruzo T.A., Durigon E.L., Hayashi Y., Gouvea V., and Palombo E.A., J Clin Microbiol 38, 2443-2446, 2000.
Palombo E.A., Bugg H.C., Masendycz P.J., and Bishop R.F., DNA Seq 7, 307-311, 1997.
Okada J., Urasawa T., Kobayashi N., Taniguchi K., Hasegawa A., Mise K., and Urasawa S., J Med Virol 60, 63-69, 2000.
Bellinzoni R.B., Mattion N.M., Matson D.O., Blackhall J., La Torre J.L., Scodeller E.A., Urasawa S., Taniguchi K., and Estes M.K., J Clin Microbiol 32, 269-272, 1990.
Ciarlet M. and Liprandi F., J Clin Microbiol 32, 269-272, 1994.
Santos N., Lima R.C., Nozawa C.M., Linhares R.E., and Gouvea V., J Clin Microbiol 37, 2734-2736, 1999.
Gouvea V., Santos N., and Timenetsky M.d., J Clin Microbiol 32, 1338-1340, 1994.
Ciarlet M., Isa P., Conner M.E., and Liprandi F., Virus Genes 22, 5-20, 2001.
Taniguchi K., Urasawa T., and Urasawa S., Virology 200, 390-400, 1994.
Li B., Hoshino Y., and Gorziglia M., Arch Virol 141, 155-160, 1996.
Mattion N.M., Cohen J., and Estes M.K., The rotavirus proteins, In: Kapikian A.Z. (ed.), Viral Infections of the Gastrointestinal Tract. Marcel Dekker Inc., New York, pp. 169-249, 1994.
Shirane K., Nakagomi O., Microbiol Immunol 38, 823-826, 1994.
Masendycz P.J., Palombo E.A., FEMS Microbiol Lett 198, 147-150.
Dunn S.J., Cross T.L., and Greenberg H.B., Virology 203, 178-183, 1994.
Kojima K., Taniguchi K., and Kobayashi N., Arch Virol 141, 1-12, 1996.
Fujiwara Y. and Nakagomi O., J Clin Microbiol 35, 2703-2705, 1997.
Patton J.T., Salter-Cid L., Kalbach A., Mansell E.A., and Kattoura M., Virology 192, 438-446, 1993.
Kirkwood C.D. and Palombo E.A., Virology 236, 258-265, 1997.
Horie Y., Masamune O., and Nakagomi O., J Gen Virol 78, 2341-2346, 1997.
Cunliffe N.A., Woods P.A., Leite J.P., Das B.K., Ramachandran M., Bhan M.K., Hart C.A., and Glass R.I., Gentsch J.R., J Med Virol 53, 41-50, 1997.
Kojima K., Taniguchi K., Urasawa T., and Urasawa S., Virology 224, 446-452, 1996.
Ciarlet M., Liprandi F., Conner M.E., and Estes M.K., Arch Virol 145, 371-383, 2000.
Barnes G.L., Lund J.S., Adams L., Mora A., Mitchell S.V., Caples A., and Bishop R.F., J Paediatr Child Health 33, 300-304, 1997.
Bernstein D.I., Smith V.E., Sherwood J.R., Schiff G.M., Sander D.S., DeFeudis D., Spriggs D.R., and Ward R.L., Vaccine 16, 381-387, 1998.
Clements-Mann M.L., Makhene M.K., Mrukowicz J., Wright P.F., Hoshino Y., Midthun K., Sperber E., Karron R., and Kapikian A.Z., Vaccine 17, 2715-2725, 1999.
Perez-Schael I., Guntinas M.J., Perez M., Pagone V., Rojas A.M., Gonzalez R., Cunto W., Hoshino Y., and Kapikian A.Z., N Engl J Med 337, 1181-1187, 1997.
Gratacap-Cavallier B., Genoulaz O., Brengel-Pesce K., Soule H., Innocenti-Francillard P., Bost M., Gofti L., Zmirou D., and Seigneurin J.M., Appl Environ Microbiol 66, 2690-2692, 2000.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Palombo, E.A. Genetic Analysis of Group A Rotaviruses: Evidence for Interspecies Transmission of Rotavirus Genes. Virus Genes 24, 11–20 (2002). https://doi.org/10.1023/A:1014073618253
Issue Date:
DOI: https://doi.org/10.1023/A:1014073618253