Abstract
The biomimetic approach allows the coating of metal implants with different calcium-phosphate (Ca-P) phases. Films elaborated at physiological conditions exhibited structures closely resembling those of bone mineral. For instance, octacalcium phosphate (OCP, Ca8(HPO4)2(PO4)4 · 5H2O) crystals have been deposited on titanium through a two-step procedure. After cleaning and etching, Ti6Al4V plates were immersed for 24 h into a simulated body fluid (SBF1). A thin amorphous carbonated Ca-P layer precipitated on the metal substrate. Secondly, these thinly Ca-P coated titanium substrates were immersed for 48 h into another simulated body fluid (SBF2). The thin amorphous carbonated Ca-P layer induced the fast precipitation of a second Ca-P layer of 55 μm in thickness composed of OCP crystals. The measurements of Ca and P concentrations versus soaking time in SBF2 showed that the carbonated Ca-P layer partially dissolved before the deposition of the OCP coating. X-ray diffraction (XRD) revealed that OCP crystals grew epitaxially on the substrate. OCP is known to be one of the precursors during the bone mineralization process, thereby, this new generation of biomimetic coatings are promising for orthopedic surgery. © 2001 Kluwer Academic Publishers
Similar content being viewed by others
References
R. G. T. Geesink and N. H. M. Hoefnagels, J. Bone Joint Surg. 77B (1995) 534.
T. Kokubo, H. Kushitani, Y. Abe and T. Yamamuro, Bioceramics 2 (1990) 235.
P. Layrolle, C. A. Van Blitterswijk and K. De Groot, Bioceramics 11 (1998) 465.
F. Barrere, P. Layrolle, C. A. Van Blitterswijk, K. De Groot, Mat. Res. Symp. Proc. 599 (2000) 135.
P. Li, I. Kanganesniemi, K. De Groot and T. Kokubo, J. Am. Ceram. Soc. 77 (1994) 1307.
T. Peltola, M. Patsi, H. Rahiala, I. Kangasniemi and A. Yli-Urpo, J. Biomed. Mater. Res. 41 (1998) 504.
P. Li and P. Ducheyne, J. Biomed. Mater. Res. 41 (1998) 341.
R. Z. Legeros, in “Biological and Synthetic Apatites in Hydroxyapatite and Related Materials” edited by P. W. Brown and B. Constanz (CRC Press, Roca-Batton, 1994) p. 3.
W. E. Brown, Nature 196 (1962) 1048.
F. Sugihara, H. Oonishi, S. Kushitani, N. Iwaki, Y. Mandai, K. Minamigawa, E. Tshuji, M. Yoshikawa and T. Toda, Bioceramics 8 (1995) 89.
O. Suzuki, M. Nakamura, Y. Miyasaka, M. Kagayama and M. Sakurai, Tohoku J. Exp. Med. 164 (1991) 37-50.
F. Barrere, P. Layrolle, C. A. Van Blitterswijk and K. De Groot, Bone 25 (1999) 107S.
B. O. Fowler, M. Markovic and W. E. Brown, Chem. Mater 15 (1993) 1417.
Joint Comity for Powder Diffraction Standards, OCP 26-1056 (1992).
E. D. Eanes and J. L. Meyer, Calcif. Tiss. Res. 23 (1977) 259.
E. C. Moreno and K. Varughese, J. Crystal Growth 53 (1981) 20.
R. Z. Legeros, R. Kijkowska and J. P. Legeros, Scan. Elec. Micros. IV (1984) 1771.
P. T. Cheng and K. P. H. Pritzker, Calcif. Tissues Int. 35 (1983) 596.
M. Hjima, H. Kamemizu, N. Wakamatsu, T. Goto, Y. Doi and Y. Moriwaki, J. Crystal Growth 112 (1991) 467.
M. J. J. M. Van Kemenade and P. L. De Bruijn, J. Colloid Interface Sci. 118 (1987) 564
J. C. Heughebaert and G. H. Nancollas, J. Phys. Chem. 88 (1984) 2478.
R. Z. Le Geros, G. Daculsi, I. Orly, T. Abergas and W. Torres, Scan. Micros. 1 (1989) 129.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Barre`re, F., Layrolle, P., van Blitterswijk, C. et al. Biomimetic coatings on titanium: a crystal growth study of octacalcium phosphate. Journal of Materials Science: Materials in Medicine 12, 529–534 (2001). https://doi.org/10.1023/A:1011271713758
Issue Date:
DOI: https://doi.org/10.1023/A:1011271713758