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Benzafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal β-oxidation in rat white adipose tissue

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Abstract

Rats treated with bezafibrate, a PPAR activator, gain less body weight and increase daily food intake. Previously, we have related these changes to a shift of thermogenesis from brown adipose tissue to white adipose tissue attributable to bezafibrate, which induces uncoupling proteins (UCP), UCP-1 and UCP-3, in rat white adipocytes. Nevertheless, UCP induction was weak, implying additional mechanisms in the change of energy homeostasis produced by bezafibrate. Here we show that bezafibrate, in addition to inducing UCPs, modifies energy homeostasis by directly inducing aco gene expression and peroxisomal fatty acid β-oxidation in white adipose tissue. Further, bezafibrate significantly reduced plasma triglyceride and leptin concentrations, without modifying the levels of PPARγ or ob gene in white adipose tissue. These results indicate that bezafibrate reduces the amount of fatty acids available for triglyceride synthesis in white adipose tissue.

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Authors and Affiliations

  1. Unidad de Farmacología y Farmacognosia, Departamento Farmacología y Química Terapéutica, Facultad de Farmacia, Núcleo Universitario de Pedralbes, Barcelona, E-08028, Spain

    Manuel Vásquez, Núria Roglans, Ágatha Cabrero, Cristina Rodríguez, Tomás Adzet, Marta Alegret, Rosa Ma Sánchez & Juan C. Laguna

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  1. Manuel Vásquez
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  2. Núria Roglans
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  3. Ágatha Cabrero
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  4. Cristina Rodríguez
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  5. Tomás Adzet
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  6. Marta Alegret
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  7. Rosa Ma Sánchez
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  8. Juan C. Laguna
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Correspondence to Juan C. Laguna.

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Vásquez, M., Roglans, N., Cabrero, Á. et al. Benzafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal β-oxidation in rat white adipose tissue. Mol Cell Biochem 216, 71–78 (2001). https://doi.org/10.1023/A:1011060615234

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