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Poly(ADP-ribosylation) and apoptosis

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Abstract

Poly(ADP-ribosylation) is a post-translational modification playing a relevant role in DNA damage recovery, DNA replication and viral integration. Several reports also suggest a modulation of this process during cell death by apoptosis. The aim of this review is to discuss the possible involvement of poly(ADP-ribosylation) during apoptosis, by dealing with general considerations on apoptosis, and further examining the correlation between NAD consumption and cell death, the regulation of poly(ADP-ribose) metabolism in apoptotic cells, the effect of poly(ADP-ribose) polymerase inhibition on cell death occurrence and the use of enzyme cleavage as a marker of apoptosis. Finally, the future prospects of the research in this area will be addressed.

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  1. Istituto di Genetica Biochimica ed Evoluzionistica del C.N.R., Via Abbiategrasso 207, Pavia, Italy

    A. Ivana Scovassi

  2. Health and Environment Unit, CHUL Research Center, Québec, Canada

    Guy G. Poirier

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  1. A. Ivana Scovassi
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Ivana Scovassi, A., Poirier, G.G. Poly(ADP-ribosylation) and apoptosis. Mol Cell Biochem 199, 125–137 (1999). https://doi.org/10.1023/A:1006962716377

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