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Sentinel lymph node: established and new areas of use

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Abstract

Sentinel lymph node studies using radiotracer techniques with pre-operative lymphatic mapping image and intra-operative gamma probe localization decrease surgical time, patient’s morbidity and improve staging accuracy. This in turn leads to improved treatment, quality of life and higher long-term survival rates. Surgeons, pathologist and nuclear medicine physicians need to work synergistically to explore and exploit the full benefits offered by this technique. The purpose of this article is to provide the reader with a concise overview on the applications and implications of sentinel lymph node biopsy procedure since its introduction into clinical practice approximately 25 years ago, but with main focus on recently consolidated areas and also the potential new areas for future expansion of this simple yet exquisite technique. The literature search included all relevant sentinel lymph node studies (reviews, meta-analysis, original articles, feasibility and case reports) utilizing radioisotopes in the areas discussed herewith from PubMed and Cochrane library.

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References

  1. Selverstone B, Solomon AK (1949) Location of brain tumors by means of radioactive phosphorus. J Am Med Assoc 140(3):277

    Article  CAS  PubMed  Google Scholar 

  2. Cabanas RM (1977) An approach for the treatment of penile carcinoma. Cancer 39(2):456–466

    Article  CAS  PubMed  Google Scholar 

  3. Morton DL (1992) Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 127(4):392–399

    Article  CAS  PubMed  Google Scholar 

  4. Krag DN, Weaver D (1993) Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol 2(6):335–339

    Article  CAS  PubMed  Google Scholar 

  5. Goldhirsch A, Glick JH (2001) Meeting highlights: international consensus panel on the treatment of primary breast cancer. Seventh Int Conf Adjuv Ther Prim Breast Cancer 19:3817–3827

    CAS  Google Scholar 

  6. Lyman GH, Giuliano AE (2005) American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol 23(30):7703–7720

    Article  PubMed  Google Scholar 

  7. Krag DN, Anderson SJ (2010) Sentinel-lymph-node resection compared with conventional axillary lymph-node dissection in clinically node negative patients with breast cancer: overall survival findings from the NSABPB-32 randomised phase 3 trial. Lancet Oncol 11(10):927–933

    Article  PubMed Central  PubMed  Google Scholar 

  8. Ashikaga T, Krag DN (2010) Morbidity results from the NSABP B32 trial comparing sentinel lymph node dissection versus axillary dissection. J Surg Oncol 102(2):111–118

    Article  PubMed Central  PubMed  Google Scholar 

  9. Mansel RE, Fallowfield L (2006) Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial. J Natl Cancer Inst 98(9):599–609

    Article  PubMed  Google Scholar 

  10. Rodier JF, Velten M (2007) Prospective multicentric randomized study comparing periareolar and peritumoral injection of radiotracer and blue dye for the detection of sentinel lymph node in breast sparing procedures: FRANSENODE trial. J Clin Oncol 25(24):3664–3669

    Article  PubMed  Google Scholar 

  11. Giuliano AE, Hunt KK (2011) Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 305(6):569–575

    Article  CAS  PubMed  Google Scholar 

  12. Morton DL, Thompson JF (2014) Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med 370(7):599–609

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Balch CM, Gershenwald JE (2014) Clinical value of the sentinel-node biopsy in primary cutaneous melanoma. N Engl J Med 370(7):663–664

    Article  CAS  PubMed  Google Scholar 

  14. Wong SL, Balch CM (2012) Sentinel lymph node biopsy for melanoma: American Society of clinical oncology and society of surgical oncology joint clinical practice guideline. Ann Surg Oncol 19:3313–3324

    Article  PubMed  Google Scholar 

  15. Matthey-Giè M, Boubaker A (2013) Sentinel lymph node biopsy in nonmelanoma skin cancer patients. J Skin Cancer 2013:267474

    Article  PubMed Central  PubMed  Google Scholar 

  16. Alkureishi LW, Ross GL (2010) Sentinel node biopsy in head and neck Squamous cell cancer: 5-year follow-up of a European multicenter trial. Ann Surg Oncol 17:2459–2464

    Article  PubMed  Google Scholar 

  17. Civantos FJ, Zitsch RP (2010) Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1–T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. J Clin Onco 28(8):1395–1400

    Article  Google Scholar 

  18. Thompson CF, St John MA (2013) Diagnostic value of sentinel lymph node biopsy in head and neck cancer: a meta-analysis. Eur Arch Otorhinolaryngol 270(7):2115–2122

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Alkureishi LW, Burak Z (2009) Joint practice guidelines for radionuclide lymphoscintigraphy for sentinel node localization in oral/oropharyngeal squamous cell carcinoma. Eur J Nucl Med Mol Imaging 36(11):1915–1936

    Article  PubMed Central  PubMed  Google Scholar 

  20. Ornellas AA, Seixas AL (1994) Surgical treatment of invasive squamous cell carcinoma of the penis: retrospective analysis of 350 cases. J Urol 151(5):1244–1249

    CAS  PubMed  Google Scholar 

  21. Culkin DJ (2003) Advanced penile carcinoma. J Urol 170(2):359–365

    Article  PubMed  Google Scholar 

  22. Pizzocaro G, Algaba F (2010) EAU penile cancer guidelines 2009. Eur Urol 57(6):1002–1012

    Article  PubMed  Google Scholar 

  23. Graafland NM, Leijte JA (2010) Repeat dynamic sentinel node biopsy in locally recurrent penile carcinoma. BJU Int 105(8):1121–1124

    Article  PubMed  Google Scholar 

  24. Meads C, Sutton AJ (2014) Sentinel lymph node biopsy in vulval cancer: systematic review and meta-analysis. Br J Cancer 110(12):2837–2846

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Cibula D, Oonk MH (2015) Sentinel lymph node biopsy in the management of gynecologic cancer. Curr Opin Obstet Gynecol 27(1):66–72

    Article  PubMed  Google Scholar 

  26. Giammarile F, Bozkurt MF, Cibula D, Pahisa J, Oyen WJ, Paredes P, Olmos RV, Sicart SV (2014) The EANM clinical and technical guidelines for lymphoscintigraphy and sentinel node localization in gynaecological cancers. Eur J Nucl Med Mol Imaging 41(7):1463–1477

    Article  PubMed  Google Scholar 

  27. Zarganis P, Kondi-Pafiti A, Arapantoni-Dadioti P et al (2009) The sentinel node in cervical cancer patients: role of tumor size and invasion of lymphatic vascular space. In Vivo 23:469–473

    PubMed  Google Scholar 

  28. Altgassen C, Hertel H (2008) Multicenter validation study of the sentinel lymph node concept in cervical cancer: AGO Study Group. J Clin Oncol 26:2943–2951

    Article  PubMed  Google Scholar 

  29. Creasman WT, Morrow CP (1987) Surgical pathologic spread patterns of endometrial cancer: a gynecologic oncology group study. Cancer 60(8):2035–2041

    Article  CAS  PubMed  Google Scholar 

  30. DiSaia PJ, Creasman WT (1985) Risk factors and recurrent patterns in stage I endometrial cancer. Am J Obstet Gynecol 151:1009–1015

    Article  CAS  PubMed  Google Scholar 

  31. Wolfson AH, Sightler SS (1993) The prognostic significance of surgical staging for carcinoma of the endometrium. Gynecol Oncol 45:142–146

    Article  Google Scholar 

  32. Greven KM, Lanciano RM (1993) Pathologic stage III endometrial carcinoma: prognostic factors and patterns of recurrence. Cancer 71:3697–3702

    Article  CAS  PubMed  Google Scholar 

  33. Mariani A, Webb MJ (2001) Significance of pathologic patterns of pelvic lymph node metastases in endometrial cancer. Gynecol Oncol 80:113–120

    Article  CAS  PubMed  Google Scholar 

  34. Koh WJ, Greer BE, Abu-Rustum NR (2014) Uterine neoplasms, version 1.2014. J Natl Compr Canc Netw 12(2):248–280

    CAS  PubMed  Google Scholar 

  35. Ballester M, Dubernard G (2011) Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO). Lancet Oncol 12:469–476

    Article  PubMed  Google Scholar 

  36. Perzyło K, Miotła P (2013) Therapeutic and prognostic value of lymphadenectomy in gynecological oncology. Ginekol Pol 84(7):630–636

    PubMed  Google Scholar 

  37. Kleppe M, Brans B (2014) The detection of sentinel nodes in ovarian cancer: a feasibility study. J Nucl Med 55(11):1799–1804

    Article  PubMed  Google Scholar 

  38. Burkhard FS (2005) The role of lymphadenectomy in prostate cancer. Nat Clin Pract Urol 2:336–342

    Article  PubMed  Google Scholar 

  39. Wawroschek FV (2003) Prostate lymphoscintigraphy and radio-guided surgery for sentinel lymph node identification in prostate cancer. Technique and results of the first 350 cases. Urol Int 70:303–310

    Article  PubMed  Google Scholar 

  40. de Bonilla-Damiá A, Roberto Brouwer O (2012) Lymphatic drainage in prostate carcinoma assessed by lymphoscintigraphy and SPECT/CT: its importance for the sentinel node procedure. Rev Esp Med Nucl Imagen Mol 31(2):66–70

    PubMed  Google Scholar 

  41. Joniau S, Van den Bergh L (2013) Mapping of pelvic lymph node metastases in prostate cancer. Eur Urol 63:450–458

    Article  PubMed  Google Scholar 

  42. Mattei A, Fuechsel FG (2008) The template of the primary lymphatic landing sites of the prostate should be revisited: results of a multimodality mapping study. Eur Urol 53:118–125

    Article  PubMed  Google Scholar 

  43. Meinhardt W, van der Poel HG (2012) Laparoscopic sentinel lymph node biopsy for prostate cancer: the relevance of locations outside the extended dissection area. Prostate Cancer 2012:751753

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  44. Holl G, Dorn R (2009) Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients. Eur J Nucl Med Mol Imaging 36:1377–1382

    Article  CAS  PubMed  Google Scholar 

  45. Ponholzer A, Lamche M (2012) Sentinel lymphadenectomy compared to extended lymphadenectomy in men with prostate cancer undergoing prostatectomy. Anticancer Res 32(3):1033–1036

    PubMed  Google Scholar 

  46. Heidenreich A, Bellmunt J (2011) EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease. Eur Urol 59(1):61–71

    Article  PubMed  Google Scholar 

  47. Tanis PJ, Horenblas S, Valdés-Olmos RA et al (2002) Feasibility of sentinel node lymphoscintigraphy in stage I testicular cancer. Eur J Nucl Med Mol Imaging 29:670–673

    Article  PubMed  Google Scholar 

  48. Brouwer OR, Valdés-Olmos RA, Vermeeren L et al (2011) SPECT/CT and a portable gamma-camera for image-guided laparoscopic sentinel node biopsy in testicular cancer. J Nucl Med 52:551–554

    Article  PubMed  Google Scholar 

  49. Giammarile F, Vidal-Sicart S, Valdés Olmos RA (2014) Uncommon applications of sentinel lymph node mapping: urogenital cancers. Q J Nucl Med Mol Imaging 58(2):161–179

    CAS  PubMed  Google Scholar 

  50. Konety BJ (2003) Extent of pelvic lymphadenectomy and its impact on outcome in patients diagnosed with bladder cancer: analysis of data from the surveillance, epidemiology and end results program data base. J Urol 169:946–950

    Article  PubMed  Google Scholar 

  51. Stein JL (2001) Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1054 patients. J Clin Oncol 19:666–675

    CAS  PubMed  Google Scholar 

  52. Abol-Enein H, El-Baz M, Abd El-Hameed MA, Abdel-Latif M, Ghoneim MA (2004) Lymph node involvement in patients with bladder cancer treated with radical cystectomy: a patho-anatomical study—a single center experience. J Urol 172:1818–1821

    Article  PubMed  Google Scholar 

  53. Herr HB (2002) Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer. J Urol 167:1295–1298

    Article  PubMed  Google Scholar 

  54. Leissner JH (2000) Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis. BJU Int 85:817–823

    Article  CAS  PubMed  Google Scholar 

  55. Abdel-Latif M, Abol-Enein H, El-Baz M, Ghoneim MA (2004) Nodal involvement in bladder cancer cases treated with radical cystectomy: incidence and prognosis. J Urol 172:85–89

    Article  PubMed  Google Scholar 

  56. Roehrborn CS (1991) Long-term patient survival after cystectomy for regional metastatic transitional cell carcinoma of the bladder. J Urol 146:36–39

    CAS  PubMed  Google Scholar 

  57. Leissner J, Ghoneim MA, Abol-Enein H, Thuroff JW, Franzaring L, Fisch M, Schulze H, Managadze G, Allhoff EP, el-Baz MA, Kastendieck H, Buhtz P, Kropf S, Hohenfellner R, Wolf HK (2004) Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study. J Urol 171:139–144

    Article  CAS  PubMed  Google Scholar 

  58. Sherif A, De La Torre M (2001) Lymphatic mapping and detection of sentinel nodes in patients with bladder cancer. J Urol 166:812–815

    Article  CAS  PubMed  Google Scholar 

  59. Liedberg F, Chebil G (2006) Intraoperative sentinel node detection improves nodal staging in invasive bladder cancer. J Urol 175:84–89

    Article  PubMed  Google Scholar 

  60. Skinner D (1981) Technique of radical cystectomy. Urol Clin North Am 8:353–366

    CAS  PubMed  Google Scholar 

  61. Sherif AM, Eriksson E (2012) Sentinel node detection in renal cell carcinoma. A feasibility study for detection of tumour draining lymph nodes. BJU Int 109(8):1134–1139

    Article  PubMed  Google Scholar 

  62. Henry JF, Gramatica L, Denizot A, Kvachenyuk A, Puccini M, Defechereux T (1998) Morbidity of prophylactic lymph node dissection in the central neck area in patients with papillary thyroid carcinoma. Langenbeck’s Arch Surg 383:167–169

    CAS  Google Scholar 

  63. British Thyroid Association, Royal College of Physicians. (2007). Guidelines for the management of thyroid cancer (Perros P, ed) 2nd edition. Report of the Thyroid Cancer Guidelines Update Group. London: Royal College of Physicians, p 92

  64. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F (2009) Revised management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19:1167–1214

    Article  PubMed  Google Scholar 

  65. Balasubramanian S, Harrison BJ (2011) Systematic review and meta-analysis of sentinel node biopsy in thyroid cancer. Br J Surg 98:332–344

    Article  Google Scholar 

  66. Cobin et al (2001) AACE/AAES medical/surgical guidelines for clinical practice: management of thyroid carcinoma. Endocr Pract 7(3):202–220

    Article  CAS  PubMed  Google Scholar 

  67. Takami H, Sasaki K, Ikeda Y, Tajima G, Kameyama K (2002) Thyroid sentinel lymph node biopsy in patients with thyroid carcinoma. Biomed Pharmacother 56:83s–87s

    Article  PubMed  Google Scholar 

  68. Sakorafas GH, Sampanis D, Safioleas M (2010) Cervical lymph node dissection in papillary thyroid cancer: current trends, persisting controversies, and unclarified uncertainties. Surg Oncol 19:e57–e70

    Article  PubMed  Google Scholar 

  69. Kelemen PR, VanHerle AJ, Giuliano AE (1998) Sentinel lymphadenectomy in thyroid malignant neoplasms. Arch Surg 133:288–292

    Article  CAS  PubMed  Google Scholar 

  70. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62:10–29

    Article  PubMed  Google Scholar 

  71. Mountain CF, Dresler CM (1997) Regional lymph node classification for lung cancer staging. Chest 111:1718–1723

    Article  CAS  PubMed  Google Scholar 

  72. Allen MS, Darling G, Pechet T et al (2006) Morbidity and mortality of major pulmonary resection in patients with early stage lung cancer initial results of the randomized, prospective ACOSOG Z0030 Trial. Ann ThoracSurg 81:1013–1019

    Article  Google Scholar 

  73. Liptay MJ, Masters GA, Winchester DJ et al (2000) Intraoperative radioisotope sentinel lymph node mapping in non-small cell lung cancer. Ann Thorac Surg 70:384–389 ; discussion 389-90

    Article  CAS  PubMed  Google Scholar 

  74. Tiffet O, Nicholson AG, Khaddage A et al (2005) Feasibility of the detection of the sentinel lymph node in peripheral non-small cell lung cancer with radio isotopic and blue dye techniques. Chest 127:443–448

    Article  PubMed  Google Scholar 

  75. Rzyman W, Hagen OM, Dziadziuszko R et al (2006) Intraoperative, radio-guided sentinel lymph node mapping in 110 nonsmall cell lung cancer patients. Ann Thorac Surg 82:237–242

    Article  PubMed  Google Scholar 

  76. Melfi FM, Chella A, Menconi GF et al (2003) Intraoperative radioguided sentinel lymph node biopsy in non-small cell lung cancer. Eur J Cardiothorac Surg 23:214–220

    Article  PubMed  Google Scholar 

  77. Kubuschok B, Passlick B, Izbicki Jr et al (1999) Disseminated tumor cells in lymph nodes as a determinant for survival in surgically resected non-small cell lung cancer. J Clin Oncol 17:19–24

    CAS  PubMed  Google Scholar 

  78. Riquet M, Manac’h D, Pimpec-Barthes F et al (1999) Prognostic significance of surgical-pathologic N1 disease in non-small cell carcinoma of the lung. Ann Thorac Surg 67:1572–1576

    Article  CAS  PubMed  Google Scholar 

  79. Tezel C, Ersev AA, Kiral H et al (2006) The impact of immunehistochemicaldetection of positive lymph nodes in early stage lung cancer. Thorac Cardiovasc Surg 54:124–128

    Article  CAS  PubMed  Google Scholar 

  80. Nosotti M, Falleni M, Palleschi A et al (2005) Quantitative real time polymerase chain reaction detection of lymph node lung cancer micrometastasis using carcinoembryonic antigen marker. Chest 128:1539–1544

    Article  PubMed  Google Scholar 

  81. Khullar O, Frangioni JV, Colson Y (2009) Image-guided sentinel lymph node mapping and nanotechnology-based nodal treatment in lung cancer using invisible near-infrared fluorescent light. Semin Thorac Cardiovasc Surg 21:309–315

    Article  PubMed Central  PubMed  Google Scholar 

  82. Nakagawa T, Minamiya Y, Katayose Y et al (2003) A novel method for sentinel lymph node mapping using magnetite in patients with non-small cell lung cancer. J Thorac Cardiovasc Surg 126:563–567

    Article  PubMed  Google Scholar 

  83. Sugi K, Kobayashi S, Yagi R, Matsuoka T (2008) Sentinel node mapping and micrometastasis in patients with clinical stage IA non-small cell lung cancer. Interact CardioVasc Thorac Surg 7:913–991

    Article  PubMed  Google Scholar 

  84. Nomori H, Kohno M, Izumi Y, Ohtsuka T, Asakura K, Nakayama T (2011) Sentinel nodes in lung cancer: review of our 10-year experience. Surg Today 41(7):889–895

    Article  PubMed  Google Scholar 

  85. Filip B, Scarpa M (2014) Minimally invasive surgery for esophageal cancer: a review on sentinel node concept. Surg Endosc 28(4):1238–1249

    Article  PubMed  Google Scholar 

  86. Tsai JA, Celebioglu F (2013) Hybrid SPECT/CT imaging of sentinel nodes in esophageal cancer: first results. Acta Radiol 54(4):369–373

    Article  PubMed  Google Scholar 

  87. Japanese Gastric Cancer Association (2011) Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer 14(2):113–123

    Article  Google Scholar 

  88. Kitagawa Y, Takeuchi H (2013) Sentinel node mapping for gastric cancer: a prospective multicenter trial in Japan. J Clin Oncol 31:3704–3710

    Article  PubMed  Google Scholar 

  89. Fielding LP, Arsenault PA (1991) Clinicopathological staging for colorectal cancer: an international documentation system (IDS) and an international comprehensive anatomical terminology (ICAT). J Gastroenterol Hepatol 6:325–344

    Article  CAS  PubMed  Google Scholar 

  90. Saha S, Johnston G (2013) Aberrant drainage of sentinel lymph nodes in colon cancer and its impact on staging and extent of operation. Am J Surg 205:302–305

    Article  PubMed  Google Scholar 

  91. Tehranian S, Treglia G, Krag DN, Dabbagh KVR, Zakavi SR, Sadeghi R, Keshtgar M (2013) Sentinel node mapping in anal canal cancer: systematic review and meta-analysis. J Gastrointestin Liver Dis 22(3):321–328

    PubMed  Google Scholar 

  92. Georgios P, Dorothy V, Anastasios T, Anastasia A, Stamatis V (2011) Sentinel node biopsy for breast cancer patients: issues for discussion and our practice. Pathol Res Int 2011:8. doi:10.4061/2011/109712

    Google Scholar 

  93. Mirk P, Treglia G, Salsano M, Basile P, Giordano A, Bonomo L (2011) Comparison between 18F-fluorodeoxyglucose positron emission tomography and sentinel lymph node biopsy for regional lymph nodal staging in patients with melanoma: a review of the literature. Radiol Res Pract. 2011(2011):912504. doi:10.1155/2011/912504

    PubMed Central  PubMed  Google Scholar 

  94. Thompson CF, St. John MA, Lawson G, Grogan T, Elashoff D, Mendelsohn AH (2013) Diagnostic value of sentinel lymph node biopsy in head and neck cancer: a meta-analysis. Eur Arch Otorhinolaryngol 270(7):2115–2122

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  95. Sadeghi R, Gholami H, Zakavi SR, Kakhki VR, Tabasi KT, Horenblas S (2012) Accuracy of sentinel lymph node biopsy for inguinal lymph node staging of penile squamous cell carcinoma: systematic review and meta-analysis of the literature. J Urol 2012(187):25–31

    Article  Google Scholar 

  96. Meads C, Sutton A, Malysiak S, Kowalska M, Zapalska A, Rogozinska E et al (2013) Sentinel lymph node status in vulval cancer: systematic reviews of test accuracy and decision-analytic model-based economic evaluation. Health Technol Assess 17(60):1–216

    Article  Google Scholar 

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Dr. Ziauddin Zia Saad has no conflicts of interest. Prof. John Buscombe is a paid consultant of Navidea.

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  1. Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK

    Ziauddin Zia Saad

  2. Addenbrooke’s Nuclear Medicine and PET, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

    John R. Buscombe

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Saad, Z.Z., Buscombe, J.R. Sentinel lymph node: established and new areas of use. Clin Transl Imaging 3, 225–236 (2015). https://doi.org/10.1007/s40336-015-0123-1

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