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Pain in Osteoporosis: From Pathophysiology to Therapeutic Approach

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Abstract

The high worldwide prevalence of osteoporosis means it is considered a serious public health concern, possibly leading to physical disability and an increased mortality rate. Although osteoporosis is known as a silent disease affecting aging populations, its primary symptom remains pain. Acute pain is reported by patients with osteoporosis-related fractures, but chronic pain, mainly back pain, is also a characteristic of severe osteoporosis. Pain is associated not only with fractures but also with bodily changes in patients with osteoporosis that may include sensory, affective, and cognitive aspects. Chronic pain leads to progressive loss of independence and the need for long-term care, especially in the elderly. Pain prevention is linked to the appropriate treatment of osteoporosis, and pain management in patients with osteoporosis requires a multidimensional approach to preserve and improve quality of life. Our aim was to review and discuss the main causes of pain in patients with osteoporosis and suggest possible strategies for its management and prevention.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, University Hospital of Messina, Messina, Italy

    Antonino Catalano, Nunziata Morabito, Claudia Scarcella, Giorgio Basile & Antonino Lasco

  2. Department of Cognitive Sciences, Psychology, Education and Cultural Studies, University of Messina, Messina, Italy

    Gabriella Martino

  3. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

    Agostino Gaudio

  4. Department of Clinical and Experimental Medicine, University Hospital “G. Martino”, Via C. Valeria, 98125, Messina, Italy

    Antonino Catalano

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  1. Antonino Catalano
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A Catalano, G Martino, N Morabito, C Scarcella, A Gaudio, G Basile, and A Lasco have no conflicts of interest.

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Catalano, A., Martino, G., Morabito, N. et al. Pain in Osteoporosis: From Pathophysiology to Therapeutic Approach. Drugs Aging 34, 755–765 (2017). https://doi.org/10.1007/s40266-017-0492-4

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