Abstract
A 45-year-old male with rhinocerebral mucormycosis (Rhizopus oryzae), refractory to liposomal amphotericin B and posaconazole, received isavuconazole salvage therapy. Initial isavuconazole plasma and tissue levels were 0.76–0.86 μg/mL and 1.09–1.38 μg/g. Plasma levels increased to 1.3–3.24 μg/mL with reduced comedication. Isavuconazole was well tolerated, and the patient has remained disease-free 24 months post-antifungal therapy.
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Conflict of interest
M.G. has received speaker honoraria and grants from Astellas. B.G. has received speaker honoraria from Pfizer. S.S. has received speaker honoraria and travel grants from Gilead, Pfizer and MSD. J.E. declares that he has no conflict of interest.
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Ervens, J., Ghannoum, M., Graf, B. et al. Successful isavuconazole salvage therapy in a patient with invasive mucormycosis. Infection 42, 429–432 (2014). https://doi.org/10.1007/s15010-013-0552-6
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DOI: https://doi.org/10.1007/s15010-013-0552-6